Joanna Jonska-Gmyrek1,2, Leszek Gmyrek3, Agnieszka Zolciak-Siwinska4, Maria Kowalska5, Beata Kotowicz5. 1. a Department of Radiotherapy , Maria Sklodowska-Curie Institute - Oncology Center , Warsaw , Poland. 2. b Department of Urooncology , Maria Sklodowska-Curie Institute - Oncology Center , Warsaw , Poland. 3. c Gynecological Oncology Department , The Holy Family Hospital , Warsaw , Poland. 4. d Department of Brachytherapy , Maria Sklodowska-Curie Institute - Oncology Center , Warsaw , Poland. 5. e Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics , Maria Sklodowska-Curie Institute - Oncology Center , Warsaw , Poland.
Abstract
OBJECTIVE: This retrospective study aimed to compare prognostic factors and survival between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in locally advanced cervical cancer treated at a single center. METHODS: All medical records of cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB or IIIA,B, treated between 2004 and 2012, were reviewed. We treated patients with chemoradiotherapy (CRT) followed by brachytherapy (BT). Multivariate logistic regression and Cox proportional hazard models were used to analyze clinicopathological characteristics, patterns of care and outcomes. RESULTS: We included in the analysis 161 patients (52 AC; 109 SCC). Patients with AC were younger (age 50 vs. 55 years), more likely to die from the disease (HR: 1.60; 95% CI: 1.26-2.58; p = .001) and to have disease recurrence (HR: 1.69; 95% C.I: 1.21-2.12; p = .004) than those with SCC. The other significant prognostic factors for overall survival (OS) and recurrence-free survival (RFS) in AC were FIGO stage (p = .001; p = .002), WHO status (0 vs. 1-3; p = .003; p = .04), and hemoglobin level (<12 g/dl>; p = .04; p = .02). The 5 year overall survival for stage II of AC and SCC was 63% and 82% (p = .03), and for IIIA,B it was 33.6% and 73% (p = .0005). The 5 year RFS for AC and SCC stage FIGO IIIA,B was 24% and 57% (p = .001). CONCLUSIONS: Adenocarcinoma histology negatively impacts OS and RFS for advanced cervical cancer. Histology-specific therapy may be an opportunity for survival improvement in these women.
OBJECTIVE: This retrospective study aimed to compare prognostic factors and survival between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in locally advanced cervical cancer treated at a single center. METHODS: All medical records of cervical cancerpatients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB or IIIA,B, treated between 2004 and 2012, were reviewed. We treated patients with chemoradiotherapy (CRT) followed by brachytherapy (BT). Multivariate logistic regression and Cox proportional hazard models were used to analyze clinicopathological characteristics, patterns of care and outcomes. RESULTS: We included in the analysis 161 patients (52 AC; 109 SCC). Patients with AC were younger (age 50 vs. 55 years), more likely to die from the disease (HR: 1.60; 95% CI: 1.26-2.58; p = .001) and to have disease recurrence (HR: 1.69; 95% C.I: 1.21-2.12; p = .004) than those with SCC. The other significant prognostic factors for overall survival (OS) and recurrence-free survival (RFS) in AC were FIGO stage (p = .001; p = .002), WHO status (0 vs. 1-3; p = .003; p = .04), and hemoglobin level (<12 g/dl>; p = .04; p = .02). The 5 year overall survival for stage II of AC and SCC was 63% and 82% (p = .03), and for IIIA,B it was 33.6% and 73% (p = .0005). The 5 year RFS for AC and SCC stage FIGO IIIA,B was 24% and 57% (p = .001). CONCLUSIONS:Adenocarcinoma histology negatively impacts OS and RFS for advanced cervical cancer. Histology-specific therapy may be an opportunity for survival improvement in these women.
Authors: Elen Cristiane Augusto Souza; Daniel Zaidan Santos; Jose Carlos Campos Torres; Diama Bhadra Vale; Joana Froes Bragança; Julio Cesar Teixeira Journal: Mol Clin Oncol Date: 2020-10-26
Authors: Lenny Gallardo-Alvarado; David Cantú-de León; Rebeca Ramirez-Morales; Gabriel Santiago-Concha; Salim Barquet-Muñoz; Rosa Salcedo-Hernandez; Cinthya Reyes; Sandra Perez-Alvarez; Delia Perez-Montiel; Carlos Perez-Plasencia; Elizabeth Trejo-Duran; Juan Pablo Galicia Journal: BMC Cancer Date: 2022-04-13 Impact factor: 4.430