Literature DB >> 30019210

Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.

Golo Kronenberg1,2,3, Markus Petermann3,4, Christof Dormann5, Michael Bader3,4,6, Peter Gass5, Rainer Hellweg2, Friederike Klempin7,8,9.   

Abstract

Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.

Entities:  

Keywords:  Antidepressants; BDNF; Depression; Neurogenesis; TPH2

Mesh：

Substances：

Year:  2018        PMID： 30019210     DOI： 10.1007/s00406-018-0924-0

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  25 in total

1.  Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients.

Authors:  J J Mann; K M Malone
Journal:  Biol Psychiatry       Date:  1997-01-15       Impact factor: 13.382

2.  Hippocampus-related effects of fluoxetine treatment under stressful vs enriched conditions.

Authors:  S Alboni; M van Dijk; S Poggini; G Milior; M L Perrotta; T Drenth; N Brunello; D Wolfer; C Limatola; I Amrein; F Cirulli; L Maggi; I Branchi
Journal:  Mol Psychiatry       Date:  2017-04       Impact factor: 15.992

3.  Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.

Authors:  Golo Kronenberg; Valentina Mosienko; Karen Gertz; Natalia Alenina; Rainer Hellweg; Friederike Klempin
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2015-06-23       Impact factor: 5.270

4.  Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas.

Authors:  Rainer Hellweg; Maha Zueger; Katharina Fink; Heide Hörtnagl; Peter Gass
Journal:  Neurobiol Dis       Date:  2006-09-20       Impact factor: 5.996

5.  Repeated electroconvulsive stimuli have long-lasting effects on hippocampal BDNF and decrease immobility time in the rat forced swim test.

Authors:  Bingjin Li; Katsuya Suemaru; Ranji Cui; Hiroaki Araki
Journal:  Life Sci       Date:  2007-01-27       Impact factor: 5.037

6.  Olfactory bulbectomy in mice induces alterations in exploratory behavior.

Authors:  M Zueger; A Urani; S Chourbaji; C Zacher; M Roche; A Harkin; P Gass
Journal:  Neurosci Lett       Date:  2005-02-10       Impact factor: 3.046

7.  Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice.

Authors:  Johannes Fuss; Nada M B Ben Abdallah; Frank W Hensley; Klaus-Josef Weber; Rainer Hellweg; Peter Gass
Journal:  PLoS One       Date:  2010-09-16       Impact factor: 3.240

8.  Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain.

Authors:  Juan M Lima-Ojeda; Miriam A Vogt; Natascha Pfeiffer; Christof Dormann; Georg Köhr; Rolf Sprengel; Peter Gass; Dragos Inta
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2013-04-30       Impact factor: 5.067

9.  Growth retardation and altered autonomic control in mice lacking brain serotonin.

Authors:  Natalia Alenina; Dana Kikic; Mihail Todiras; Valentina Mosienko; Fatimunnisa Qadri; Ralph Plehm; Philipp Boyé; Larissa Vilianovitch; Reinhard Sohr; Katja Tenner; Heide Hörtnagl; Michael Bader
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-11       Impact factor: 11.205

10.  Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.

Authors:  V Mosienko; B Bert; D Beis; S Matthes; H Fink; M Bader; N Alenina
Journal:  Transl Psychiatry       Date:  2012-05-29       Impact factor: 6.222
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  2 in total

Review 1.  Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine-Immune Therapeutic Mechanisms and Clinical Implications.

Authors:  Milagros Rojas; Daniela Ariza; Ángel Ortega; Manuel E Riaño-Garzón; Mervin Chávez-Castillo; José Luis Pérez; Lorena Cudris-Torres; María Judith Bautista; Oscar Medina-Ortiz; Joselyn Rojas-Quintero; Valmore Bermúdez
Journal:  Int J Mol Sci       Date:  2022-06-22       Impact factor: 6.208

Review 2.  Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling.

Authors:  Andrei Turkin; Oksana Tuchina; Friederike Klempin
Journal:  Front Cell Dev Biol       Date:  2021-05-24
  2 in total

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