Literature DB >> 26100147

Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.

Golo Kronenberg1, Valentina Mosienko2,3, Karen Gertz4, Natalia Alenina2, Rainer Hellweg1, Friederike Klempin5.   

Abstract

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.

Entities:  

Keywords:  Antidepressant; BDNF; Depression; SERT; Serotonin; TPH2

Mesh：

Substances：

Year:  2015        PMID： 26100147     DOI： 10.1007/s00406-015-0611-3

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  36 in total

1.  Effects of early visual experience and diurnal rhythms on BDNF mRNA and protein levels in the visual system, hippocampus, and cerebellum.

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Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

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Authors:  Rainer Hellweg; Peter Lohmann; Roman Huber; Alexander Kühl; Matthias W Riepe
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Review 3.  Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT.

Authors:  Laurent Descarries; Mustaph Riad
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-09-05       Impact factor: 6.237

4.  Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas.

Authors:  Rainer Hellweg; Maha Zueger; Katharina Fink; Heide Hörtnagl; Peter Gass
Journal:  Neurobiol Dis       Date:  2006-09-20       Impact factor: 5.996

Review 5.  Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis.

Authors:  Valentina Mosienko; Daniel Beis; Massimo Pasqualetti; Jonas Waider; Susann Matthes; Fatimunnisa Qadri; Michael Bader; Natalia Alenina
Journal:  Behav Brain Res       Date:  2014-06-11       Impact factor: 3.332

6.  Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.

Authors:  Hao-Wei Shen; Yoko Hagino; Hideaki Kobayashi; Keiko Shinohara-Tanaka; Kazutaka Ikeda; Hideko Yamamoto; Toshifumi Yamamoto; Klaus-Peter Lesch; Dennis L Murphy; F Scott Hall; George R Uhl; Ichiro Sora
Journal:  Neuropsychopharmacology       Date:  2004-10       Impact factor: 7.853

Review 7.  Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine.

Authors:  Laura E Halpin; Stuart A Collins; Bryan K Yamamoto
Journal:  Life Sci       Date:  2013-07-24       Impact factor: 5.037

8.  Growth retardation and altered autonomic control in mice lacking brain serotonin.

Authors:  Natalia Alenina; Dana Kikic; Mihail Todiras; Valentina Mosienko; Fatimunnisa Qadri; Ralph Plehm; Philipp Boyé; Larissa Vilianovitch; Reinhard Sohr; Katja Tenner; Heide Hörtnagl; Michael Bader
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-11       Impact factor: 11.205

9.  Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.

Authors:  Raffaella Molteni; Annamaria Cattaneo; Francesca Calabrese; Flavia Macchi; Jocelien D A Olivier; Giorgio Racagni; Bart A Ellenbroek; Massimo Gennarelli; Marco A Riva
Journal:  Neurobiol Dis       Date:  2009-12-23       Impact factor: 5.996

10.  Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.

Authors:  V Mosienko; B Bert; D Beis; S Matthes; H Fink; M Bader; N Alenina
Journal:  Transl Psychiatry       Date:  2012-05-29       Impact factor: 6.222
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  12 in total

1.  Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.

Authors:  Claudio D'Addario; Maria Carlotta Palazzo; Beatrice Benatti; Benedetta Grancini; Mariangela Pucci; Andrea Di Francesco; Giulia Camuri; Daniela Galimberti; Chiara Fenoglio; Elio Scarpini; A Carlo Altamura; Mauro Maccarrone; Bernardo Dell'Osso
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2017-08-19       Impact factor: 5.067

2.  Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.

Authors:  Kenji Hashimoto
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2016-04       Impact factor: 5.270

3.  Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders.

Authors:  Wolfgang Jordan; Henrik Dobrowolny; Sabine Bahn; Hans-Gert Bernstein; Tanja Brigadski; Thomas Frodl; Berend Isermann; Volkmar Lessmann; Jürgen Pilz; Andrea Rodenbeck; Kolja Schiltz; Edzard Schwedhelm; Hayrettin Tumani; Jens Wiltfang; Paul C Guest; Johann Steiner
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2016-12-02       Impact factor: 5.270

Review 4.  Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine-Immune Therapeutic Mechanisms and Clinical Implications.

Authors:  Milagros Rojas; Daniela Ariza; Ángel Ortega; Manuel E Riaño-Garzón; Mervin Chávez-Castillo; José Luis Pérez; Lorena Cudris-Torres; María Judith Bautista; Oscar Medina-Ortiz; Joselyn Rojas-Quintero; Valmore Bermúdez
Journal:  Int J Mol Sci       Date:  2022-06-22       Impact factor: 6.208

5.  Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.

Authors:  Golo Kronenberg; Markus Petermann; Christof Dormann; Michael Bader; Peter Gass; Rainer Hellweg; Friederike Klempin
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2018-07-17       Impact factor: 5.270

6.  Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry.

Authors:  Marta Pratelli; Sara Migliarini; Barbara Pelosi; Francesco Napolitano; Alessandro Usiello; Massimo Pasqualetti
Journal:  eNeuro       Date:  2017-04-11

7.  TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner.

Authors:  Paola Brivio; Giulia Sbrini; Polina Peeva; Mihail Todiras; Michael Bader; Natalia Alenina; Francesca Calabrese
Journal:  Front Mol Neurosci       Date:  2018-10-30       Impact factor: 5.639

8.  A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val66Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects.

Authors:  Maeson S Latsko; T Lee Gilman; Lindsey M Matt; K Maria Nylocks; Karin G Coifman; Aaron M Jasnow
Journal:  PLoS One       Date:  2016-10-03       Impact factor: 3.240

9.  Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment.

Authors:  Katarzyna Rafa-Zabłocka; Grzegorz Kreiner; Monika Bagińska; Irena Nalepa
Journal:  Front Neurosci       Date:  2018-09-20       Impact factor: 4.677

10.  Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress.

Authors:  Giacomo Maddaloni; Sara Migliarini; Francesco Napolitano; Andrea Giorgi; Serena Nazzi; Daniele Biasci; Alessia De Felice; Marta Gritti; Anna Cavaccini; Alberto Galbusera; Sara Franceschi; Francesca Lessi; Marco La Ferla; Paolo Aretini; Chiara Maria Mazzanti; Raffaella Tonini; Alessandro Gozzi; Alessandro Usiello; Massimo Pasqualetti
Journal:  Sci Rep       Date:  2018-08-07       Impact factor: 4.379
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