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Literature DB >> 3001809

Inhibition by naloxone of the rise in hypothalamic dopamine and serum prolactin induced by ethanol.

A Seilicovich, M Rubio, B Duvilanski, V Muñoz Maines, V Rettori.

Abstract

We investigated the effect of naloxone on the concentration of dopamine in the hypothalamus and on the concentration of prolactin in serum and anterior pituitary of male rats acutely treated with ethanol. Acute ethanol administration increased serum prolactin levels and hypothalamic dopamine concentration. Pituitary prolactin was not modified by this treatment. Naloxone administered 15 min before the animals were sacrificed decreased serum prolactin levels and hypothalamic dopamine concentration in ethanol-treated rats. These results suggest that ethanol increases prolactin secretion because it decreases the release of dopamine by the hypothalamus. Naloxone decreases prolactin release probably because it antagonizes the inhibitory action of opioids on dopaminergic neurons.

Entities: Chemical Disease Gene Species

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Year: 1985 PMID： 3001809 DOI： 10.1007/bf00432513

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

19 in total

Inhibition by naloxone of the rise in hypothalamic dopamine and serum prolactin induced by ethanol.

1. Relation of endogenous opioid peptides and morphine to neuroendocrine functions.

2. Reduction of striatal dopamine release during an ethanol withdrawal syndrome.

3. Noradrenergic modulation of serotonin synthesis and metabolism. I. Inhibition by clonidine in vivo.

Review 4. The neuroendocrinology of opioid peptides.

5. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.

6. High-affinity stereospecific binding of 3H-dopamine in rat brain: interaction with endogenous dopamine.

7. Activation of adenylate cyclase by ethanol in mouse striatal tissue.

8. Long-term ethanol alters the binding of 3H-opiates to brain membranes.

9. The effect of ethanol on prolactin secretion in vitro.

10. Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary.

Review 1. Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

2. Impact of acute and chronic ethanol exposure on prolactin in both male and female rats.

3. Narcotic antagonism of seizures induced by a dopamine-derived tetrahydroisoquinoline alkaloid.

4. Heightened eating drive and visual food stimuli attenuate central nociceptive processing.

Review 5. Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System.