Literature DB >> 6771806

Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary.

R Schulz, M Wüster, T Duka, A Herz.   

Abstract

Acute ethanol administration increased methionine-enkephalin (met-enkephalin) and beta-endorphin levels in distinct areas of the rat brain, whereas chronically supplied ethanol caused a depression of met-enkephalin and beta-endorphin levels in most of the brain areas investigated. The beta-endorphin content of the intermediate/posterior lobe of the pituitary of rats and guinea pigs decreased by 70%. Withdrawal of ethanol resulted in a complete recovery of endorphin levels in brain and pituitary within two weeks. Whether the observed alterations in endorphin concentrations are causally related to the primary mechanisms underlying alcohol dependence is uncertain, since no obvious signs of physical dependence were observed in treated animals.

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Year:  1980        PMID： 6771806     DOI： 10.1007/bf00428107

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

Review 1.  Biology of opioid peptides.

Authors:  A Beaumont; J Hughes
Journal:  Annu Rev Pharmacol Toxicol       Date:  1979       Impact factor: 13.820

2.  Long-term morphine treatment decreases endorphin levels in rat brain and pituitary.

Authors:  R Przewłocki; V Höllt; T Duka; G Kleber; C Gramsch; I Haarmann; A Herz
Journal:  Brain Res       Date:  1979-10-05       Impact factor: 3.252

3.  Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs.

Authors:  J S Hong; H Y Yang; W Fratta; E Costa
Journal:  J Pharmacol Exp Ther       Date:  1978-04       Impact factor: 4.030

4.  Alteration of central catecholamine metabolism following acute administration of ethanol.

Authors:  S Liljequist; A Carlsson
Journal:  J Pharm Pharmacol       Date:  1978-11       Impact factor: 3.765

5.  Hypothalamic enkephalin neurones may regulate the neurohypophysis.

Authors:  J Rossier; E Battenberg; Q Pittman; A Bayon; L Koda; R Miller; R Guillemin; F Bloom
Journal:  Nature       Date:  1979-02-22       Impact factor: 49.962

6.  Concomitant storage of ACTH- and endorphin-like immunoreactivity in the secretory granules of anterior pituitary corticotrophs.

Authors:  E Weber; K H Voigt; R Martin
Journal:  Brain Res       Date:  1978-11-24       Impact factor: 3.252

7.  beta-Endorphin-like immunoreactivity in plasma, pituitaries and hypothalamus of rats following treatment with opiates.

Authors:  V Höllt; R Przewłocki; A Herz
Journal:  Life Sci       Date:  1978-09-11       Impact factor: 5.037

8.  Distribution of methionine- and leucine-enkephalin within the rat pituitary gland measured by highly specific radioimmunoassays.

Authors:  T Duka; V Höllt; R Przewłocki; D Wesche
Journal:  Biochem Biophys Res Commun       Date:  1978-12-14       Impact factor: 3.575

9.  A comparative analysis of the effects of narcotics, alcohol and the barbiturates on the hypothalamic-pituitary-gonadal axis.

Authors:  T J Cicero; T M Badger
Journal:  Adv Exp Med Biol       Date:  1977       Impact factor: 2.622

10.  Common precursor to corticotropins and endorphins.

Authors:  R E Mains; B A Eipper; N Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205
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  33 in total

Review 1.  Endorphins: the basis of pleasure?

Authors:  C H Hawkes
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

2.  Importance of delta opioid receptors in maintaining high alcohol drinking.

Authors:  J C Froehlich; M Zweifel; J Harts; L Lumeng; T K Li
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

3.  Regular cannabis and alcohol use is associated with resting-state time course power spectra in incarcerated adolescents.

Authors:  Sandra Thijssen; Barnaly Rashid; Shruti Gopal; Prashanth Nyalakanti; Vince D Calhoun; Kent A Kiehl
Journal:  Drug Alcohol Depend       Date:  2017-07-08       Impact factor: 4.492

4.  Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide.

Authors:  F Weiss; M Mitchiner; F E Bloom; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 5.  The opioid receptors as targets for drug abuse medication.

Authors:  Florence Noble; Magalie Lenoir; Nicolas Marie
Journal:  Br J Pharmacol       Date:  2015-06-26       Impact factor: 8.739

6.  Administration of leu-enkephalin impairs the acquisition of preference for ethanol.

Authors:  C Sandi; J Borrell; C Guaza
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

7.  Ethanol exposure differentially alters pro-enkephalin mRNA expression in regions of the mesocorticolimbic system.

Authors:  Milagros Méndez; Marcela Morales-Mulia
Journal:  Psychopharmacology (Berl)       Date:  2006-09-19       Impact factor: 4.530

8.  Investigation of the involvement of opioid receptors in the action of anticonvulsants.

Authors:  H C Jackson; D J Nutt
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

Authors:  Adolfo Sequeira; Firoza Mamdani; Carl Ernst; Marquis P Vawter; William E Bunney; Veronique Lebel; Sonia Rehal; Tim Klempan; Alain Gratton; Chawki Benkelfat; Guy A Rouleau; Naguib Mechawar; Gustavo Turecki
Journal:  PLoS One       Date:  2009-08-11       Impact factor: 3.240

Review 10.  Endogenous opioids and excessive alcohol consumption.

Authors:  C Gianoulakis
Journal:  J Psychiatry Neurosci       Date:  1993-07       Impact factor: 6.186
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