Lena Palaniyappan1, Natália Bezerra Mota2, Shamuz Oowise3, Vijender Balain4, Mauro Copelli5, Sidarta Ribeiro6, Peter F Liddle7. 1. Department of Psychiatry, Robarts Research Institute, University of Western Ontario, Lawson Health Research Institute, London, ON, Canada. Electronic address: lpalaniy@uwo.ca. 2. Brain Institute, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil; Physics Department, Federal University of Pernambuco (UFPE), Recife, Brazil. 3. The Forensic and Long Bay Hospitals, Justice and Forensic Mental Health Network, Sydney, NSW, Australia. 4. Penticton Regional Hospital, 550 Carmi Avenue, Penticton, British Columbia, Canada. 5. Physics Department, Federal University of Pernambuco (UFPE), Recife, Brazil. 6. Brain Institute, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil. 7. Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK.
Abstract
BACKGROUND: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization. METHODS: Using structural and functional imaging, we investigated the neural basis and the functional relevance of the structural connectedness of speech samples obtained from 56 patients with psychosis (22 with bipolar disorder, 34 with schizophrenia). Speech structure was assessed by non-semantic graph analysis. RESULTS: We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing speed deficits) and iv) functional outcome in patients. Of various clinical metrics, only speech connectedness was correlated with biological markers. Speech connectedness filled the dynamic range of responses better than psychometric measurements of thought disorder. CONCLUSIONS: The results provide novel evidence that speech dysconnectivity could emerge from neurodevelopmental deficits and associated dysconnectivity in psychosis.
BACKGROUND: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization. METHODS: Using structural and functional imaging, we investigated the neural basis and the functional relevance of the structural connectedness of speech samples obtained from 56 patients with psychosis (22 with bipolar disorder, 34 with schizophrenia). Speech structure was assessed by non-semantic graph analysis. RESULTS: We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing speed deficits) and iv) functional outcome in patients. Of various clinical metrics, only speech connectedness was correlated with biological markers. Speech connectedness filled the dynamic range of responses better than psychometric measurements of thought disorder. CONCLUSIONS: The results provide novel evidence that speech dysconnectivity could emerge from neurodevelopmental deficits and associated dysconnectivity in psychosis.
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