Lena S Kiefer1, Jana Fabian1, Susanne Rospleszcz2, Roberto Lorbeer3, Jürgen Machann4, Corinna Storz1, Mareen S Kraus1, Christopher L Schlett5, Frank Roemer6, Elke Wintermeyer7, Wolfgang Rathmann8, Konstantin Nikolaou1, Annette Peters9, Fabian Bamberg10. 1. Department of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany. 2. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. 3. Department of Radiology, Ludwig-Maximilian-University Hospital, Munich, Germany. 4. Section of Experimental Radiology, Department of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany; German Center for Diabetes Research (DDZ), Germany. 5. Department of Radiology, Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany. 6. Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany; Department of Radiology, Boston University School of Medicine, Boston, MA, United States. 7. BG Trauma Center, University of Tuebingen, Tuebingen, Germany. 8. German Center for Diabetes Research (DDZ), Germany. 9. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Cardiovascular Prevention, Ludwig-Maximilian-University-Hospital, Munich, Germany; German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany; Institute of Epidemiology, Ludwig-Maximilian-University-Hospital, Munich, Germany. 10. Department of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany; German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany. Electronic address: fabian.bamberg@uni-tuebingen.de.
Abstract
OBJECTIVES: Intra- and intermyocellular lipid deposition and adipose tissue are part of glucose homeostasis and insulin resistance; however, their role in type 2 diabetes mellitus (T2DM) remains unclear. We assessed differences in the degree of abdominal myosteatosis among subjects with T2DM and prediabetes. MATERIALS AND METHODS: Asymptomatic subjects from the general population were classified as subjects with T2DM, prediabetes or healthy controls and underwent multi-echo Dixon magnetic resonance imaging (MRI) (TR 8.90 ms, six echo times, flip-angle 4°). Abdominal myosteatosis was quantified as proton-density fat-fraction (PDFFmuscle) by a standardized segmentation-algorithm. Cardiometabolic risk factors were prospectively obtained in a comprehensive health assessment and visceral and subcutaneous adipose tissue (VAT and SAT) were quantified semi-automatically. Uni- and multivariate quantile regression were used to examine associations. RESULTS: Among 349 included subjects (mean age: 56.0 ± 8.0years, 56.7% males), 45 were classified as subjects with T2DM and 84 with prediabetes (12.9% and 24.1%; respectively). Median PDFFmuscle was significantly higher in subjects with T2DM and prediabetes compared to healthy controls (13.1% (IQR10.5-16.6%); 11.1% (IQR8.9-15.0%) and 10.1% (IQR7.5-13.3%); respectively, p < 0.001). The observed differences were independent of age and gender (all p < 0.002) but attenuated after adjustment for BMI (β: -0.02, 95%CI: -1.49 to 1.44, p = 0.974; β: 0.47, 95%CI: -0.91 to 1.86, p = 0.506; prediabetes and T2DM, respectively). This effect was attributable to VAT, which remained independently associated with PDFFmuscle after full adjustment (β: 0.01, 95%CI: 0.01-0.02, p = 0.002). CONCLUSIONS: There are significant differences in the degree of abdominal myosteatosis between subjects with T2DM, prediabetes and healthy controls, that may be confounded by VAT. However, abdominal myosteatosis by MRI might serve as a cardiometabolic imaging-biomarker, specifically in the setting of impaired glucose metabolism.
OBJECTIVES: Intra- and intermyocellular lipid deposition and adipose tissue are part of glucose homeostasis and insulin resistance; however, their role in type 2 diabetes mellitus (T2DM) remains unclear. We assessed differences in the degree of abdominal myosteatosis among subjects with T2DM and prediabetes. MATERIALS AND METHODS: Asymptomatic subjects from the general population were classified as subjects with T2DM, prediabetes or healthy controls and underwent multi-echo Dixon magnetic resonance imaging (MRI) (TR 8.90 ms, six echo times, flip-angle 4°). Abdominal myosteatosis was quantified as proton-density fat-fraction (PDFFmuscle) by a standardized segmentation-algorithm. Cardiometabolic risk factors were prospectively obtained in a comprehensive health assessment and visceral and subcutaneous adipose tissue (VAT and SAT) were quantified semi-automatically. Uni- and multivariate quantile regression were used to examine associations. RESULTS: Among 349 included subjects (mean age: 56.0 ± 8.0years, 56.7% males), 45 were classified as subjects with T2DM and 84 with prediabetes (12.9% and 24.1%; respectively). Median PDFFmuscle was significantly higher in subjects with T2DM and prediabetes compared to healthy controls (13.1% (IQR10.5-16.6%); 11.1% (IQR8.9-15.0%) and 10.1% (IQR7.5-13.3%); respectively, p < 0.001). The observed differences were independent of age and gender (all p < 0.002) but attenuated after adjustment for BMI (β: -0.02, 95%CI: -1.49 to 1.44, p = 0.974; β: 0.47, 95%CI: -0.91 to 1.86, p = 0.506; prediabetes and T2DM, respectively). This effect was attributable to VAT, which remained independently associated with PDFFmuscle after full adjustment (β: 0.01, 95%CI: 0.01-0.02, p = 0.002). CONCLUSIONS: There are significant differences in the degree of abdominal myosteatosis between subjects with T2DM, prediabetes and healthy controls, that may be confounded by VAT. However, abdominal myosteatosis by MRI might serve as a cardiometabolic imaging-biomarker, specifically in the setting of impaired glucose metabolism.
Authors: Derik L Davis; Jiachen Zhuo; Ranyah Almardawi; Michael E Mulligan; Charles S Resnik; Selwan B Abdullah; Hussain Al Khalifah; R Frank Henn; Mohit N Gilotra; S Ashfaq Hasan; Rao P Gullapalli Journal: AJR Am J Roentgenol Date: 2019-09-11 Impact factor: 3.959
Authors: Julie Rodriguez; Maxime Nachit; Nicolas Lanthier; Sophie Hiel; Pierre Trefois; Audrey M Neyrinck; Patrice D Cani; Laure B Bindels; Jean-Paul Thissen; Nathalie M Delzenne Journal: Sci Rep Date: 2021-01-12 Impact factor: 4.379
Authors: Lena S Kiefer; Jana Fabian; Susanne Rospleszcz; Roberto Lorbeer; Jürgen Machann; Mareen S Kraus; Marc Fischer; Frank Roemer; Wolfgang Rathmann; Christa Meisinger; Margit Heier; Konstantin Nikolaou; Annette Peters; Corinna Storz; Christopher L Schlett; Fabian Bamberg Journal: J Cachexia Sarcopenia Muscle Date: 2022-01-25 Impact factor: 12.910