Literature DB >> 30013624

Impact of an antimicrobial stewardship program on healthcare-associated Clostridium difficile rates at a community-based teaching hospital.

Matthew A Moffa1,2, Thomas L Walsh1,2, Amy Tang3, Derek N Bremmer4.   

Abstract

We conducted a pre-intervention/post-intervention study to assess the rate of healthcare-associated Clostridium difficile infections (HA-CDI) before and after the implementation of an antimicrobial stewardship program (ASP). Upon implementation of our ASP, the usage of targeted antimicrobials, including ceftriaxone, clindamycin, fluoroquinolones and carbapenem antibiotics, were significantly reduced. There was also a significant reduction in HA-CDI/1000 patient-days following ASP implementation (0.84 vs. 0.28; P = 0.035).

Entities:  

Keywords:  Antimicrobial stewardship; Clostridium difficile; antimicrobial resistance; healthcare-associated Clostridium difficile; healthcare-associated infections; infection control; infection prevention; infectious diseases; nosocomial infection

Year:  2018        PMID： 30013624      PMCID： PMC6039912          DOI： 10.1177/1757177418767760

Source DB:  PubMed          Journal:  J Infect Prev        ISSN： 1757-1782


  5 in total

1.  Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem.

Authors:  Dale N Gerding
Journal:  Clin Infect Dis       Date:  2004-02-11       Impact factor: 9.079

Review 2.  Effect of antibiotic stewardship programmes on Clostridium difficile incidence: a systematic review and meta-analysis.

Authors:  Leah M Feazel; Ashish Malhotra; Eli N Perencevich; Peter Kaboli; Daniel J Diekema; Marin L Schweizer
Journal:  J Antimicrob Chemother       Date:  2014-03-14       Impact factor: 5.790

3.  A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use.

Authors:  Carlene A Muto; Marian Pokrywka; Kathleen Shutt; Aaron B Mendelsohn; Kathy Nouri; Kathy Posey; Terri Roberts; Karen Croyle; Sharon Krystofiak; Sujata Patel-Brown; A William Pasculle; David L Paterson; Melissa Saul; Lee H Harrison
Journal:  Infect Control Hosp Epidemiol       Date:  2005-03       Impact factor: 3.254

4.  Burden of Clostridium difficile infection in the United States.

Authors:  Fernanda C Lessa; Yi Mu; Wendy M Bamberg; Zintars G Beldavs; Ghinwa K Dumyati; John R Dunn; Monica M Farley; Stacy M Holzbauer; James I Meek; Erin C Phipps; Lucy E Wilson; Lisa G Winston; Jessica A Cohen; Brandi M Limbago; Scott K Fridkin; Dale N Gerding; L Clifford McDonald
Journal:  N Engl J Med       Date:  2015-02-26       Impact factor: 91.245

5.  Multistate point-prevalence survey of health care-associated infections.

Authors:  Shelley S Magill; Jonathan R Edwards; Wendy Bamberg; Zintars G Beldavs; Ghinwa Dumyati; Marion A Kainer; Ruth Lynfield; Meghan Maloney; Laura McAllister-Hollod; Joelle Nadle; Susan M Ray; Deborah L Thompson; Lucy E Wilson; Scott K Fridkin
Journal:  N Engl J Med       Date:  2014-03-27       Impact factor: 91.245
  5 in total
  3 in total

1.  Decreasing ICU-associated Clostridioides difficile infection through fluoroquinolone restriction, the FIRST trial: a study protocol.

Authors:  Nasia Safdar; Vishala Parmasad; Roger Brown; Pascale Carayon; Alexander Lepak; John C O'Horo; Lucas Schulz
Journal:  BMJ Open       Date:  2021-06-29       Impact factor: 2.692

2.  Bibliometric analysis of peer-reviewed literature on antimicrobial stewardship from 1990 to 2019.

Authors:  Waleed M Sweileh
Journal:  Global Health       Date:  2021-01-04       Impact factor: 4.185

3.  Clinical impact of a Clostridioides (Clostridium) difficile bedside infectious disease stewardship intervention.

Authors:  María Olmedo; Maricela Valerio; Elena Reigadas; Mercedes Marín; Luis Alcalá; Patricia Muñoz; Emilio Bouza
Journal:  JAC Antimicrob Resist       Date:  2020-08-11
  3 in total

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