Literature DB >> 30010678

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Timm T Ensfelder1, Matthias Q Kurz1, Katharina Iwan1, Simon Geiger1, Sarah Matheisl2, Markus Müller1, Roland Beckmann2, Thomas Carell1.   

Abstract

RNA contains methylated A-base derivatives. A methylation to m6A and then demethylation regulate homeostasis in mRNA. It is assumed that m6A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m62A, which is a non-canonical base present in ribosomal RNA.

Entities:  

Year:  2018        PMID： 30010678     DOI： 10.1039/c8cc03980a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Detailed resume of RNA m6A demethylases.

Authors:  Dandan Shen; Bo Wang; Ya Gao; Lijuan Zhao; Yaping Bi; Jinge Zhang; Ning Wang; Huiqin Kang; Jingru Pang; Ying Liu; Luping Pang; Zhe-Sheng Chen; Yi-Chao Zheng; Hong-Min Liu
Journal:  Acta Pharm Sin B       Date:  2022-01-11       Impact factor: 14.903

Review 2.  Structural Insights Into m6A-Erasers: A Step Toward Understanding Molecule Specificity and Potential Antiviral Targeting.

Authors:  Mahmoud Bayoumi; Muhammad Munir
Journal:  Front Cell Dev Biol       Date:  2021-01-12

3.  Comprehensive Analysis of the Transcriptome-Wide m6A Methylation in Mouse Pachytene Spermatocytes and Round Spermatids.

Authors:  Shihao Hong; Xiaozhong Shen; Jinmei Cheng; Hanyu Tang; Fei Sun
Journal:  Front Genet       Date:  2022-03-17       Impact factor: 4.772

Review 4.  Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease.

Authors:  Justine Mathoux; David C Henshall; Gary P Brennan
Journal:  Front Cell Neurosci       Date:  2021-05-19       Impact factor: 5.505

5.  ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1.

Authors:  Wenqing Sun; Yan Li; Dongyu Ma; Yi Liu; Qi Xu; Demin Cheng; Guanru Li; Chunhui Ni
Journal:  Cell Mol Biol Lett       Date:  2022-03-12       Impact factor: 5.787
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.