| Literature DB >> 3000812 |
R P Ebstein, M Steinitz, J Mintzer, I Lipshitz, J Stessman.
Abstract
Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of 125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down-regulation.Entities:
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Year: 1985 PMID： 3000812 DOI： 10.1007/bf01964803
Source DB: PubMed Journal: Experientia ISSN： 0014-4754