Srishti Shrestha1, Freya Kamel1, David M Umbach2, Zheng Fan3, Laura E Beane Freeman4, Stella Koutros4, Michael Alavanja4, Aaron Blair4, Dale P Sandler1, Honglei Chen5. 1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. 2. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. 3. Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. 4. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 5. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA. Electronic address: hchen@epi.msu.edu.
Abstract
INTRODUCTION: Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies. METHODS: We screened for DEB among 20,591 male farmers in 2013-2015 using a validated question, and examined its association with pesticide uses and other potential risk factors reported about twenty years ago in 1993-1997. We reported odds ratios (OR) and 95% confidence intervals (CI) from multivariable logistic regression models. RESULTS: A total of 1623 (7.9%) farmers reported having had DEB. Farmers with DEB were more likely to report other nonmotor and motor symptoms of PD with age-adjusted ORs ranging from 1.9 to 3.0. DEB prevalence varied little by age, but was significantly associated with current smoking (adjusted OR: 1.4, 95%CI: 1.2, 1.6), daily alcohol drinking (OR: 1.4, 95%CI: 1.1, 1.6), a history of head injury (OR: 1.3, 95%CI: 1.2, 1.5), and being married (OR: 1.4, 95%CI: 1.1, 1.7). We identified significant associations for several pesticides, especially cyclodiene organochlorines and pyrethroids, with adjusted ORs ranging from 1.2 to 1.5. The results were similar after excluding PD cases or when farmers with at least three DEB episodes in life were considered as DEB cases. CONCLUSIONS: This study suggests that DEB are not rare among male farmers. Findings on potential risk factors for DEB are intriguing, and given the close link between RBD and PD, these associations should be further investigated.
INTRODUCTION:Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies. METHODS: We screened for DEB among 20,591 male farmers in 2013-2015 using a validated question, and examined its association with pesticide uses and other potential risk factors reported about twenty years ago in 1993-1997. We reported odds ratios (OR) and 95% confidence intervals (CI) from multivariable logistic regression models. RESULTS: A total of 1623 (7.9%) farmers reported having had DEB. Farmers with DEB were more likely to report other nonmotor and motor symptoms of PD with age-adjusted ORs ranging from 1.9 to 3.0. DEB prevalence varied little by age, but was significantly associated with current smoking (adjusted OR: 1.4, 95%CI: 1.2, 1.6), daily alcohol drinking (OR: 1.4, 95%CI: 1.1, 1.6), a history of head injury (OR: 1.3, 95%CI: 1.2, 1.5), and being married (OR: 1.4, 95%CI: 1.1, 1.7). We identified significant associations for several pesticides, especially cyclodiene organochlorines and pyrethroids, with adjusted ORs ranging from 1.2 to 1.5. The results were similar after excluding PD cases or when farmers with at least three DEB episodes in life were considered as DEB cases. CONCLUSIONS: This study suggests that DEB are not rare among male farmers. Findings on potential risk factors for DEB are intriguing, and given the close link between RBD and PD, these associations should be further investigated.
Authors: Aaron Blair; Robert Tarone; Dale Sandler; Charles F Lynch; Andrew Rowland; Wendy Wintersteen; William C Steen; Claudine Samanic; Mustafa Dosemeci; Michael C R Alavanja Journal: Epidemiology Date: 2002-01 Impact factor: 4.822
Authors: Robert D Abbott; G Webster Ross; Helen Petrovitch; Kamal H Masaki; Lenore J Launer; James S Nelson; Lon R White; Caroline M Tanner Journal: Neurology Date: 2015-12-09 Impact factor: 9.910
Authors: Srishti Shrestha; Freya Kamel; David M Umbach; Laura E Beane Freeman; Stella Koutros; Michael Alavanja; Dale P Sandler; Honglei Chen Journal: PLoS One Date: 2017-09-27 Impact factor: 3.240
Authors: Yaqun Yuan; Srishti Shrestha; Zhehui Luo; Chenxi Li; Brenda L Plassman; Christine G Parks; Jonathan N Hofmann; Laura E Beane Freeman; Dale P Sandler; Honglei Chen Journal: Mov Disord Date: 2022-02-13 Impact factor: 9.698
Authors: Yaping Liu; Eemil Partinen; Ngan Yin Chan; Yves Dauvilliers; Yuichi Inoue; Luigi De Gennaro; Giuseppe Plazzi; Courtney J Bolstad; Michael R Nadorff; Ilona Merikanto; Bjørn Bjorvatn; Fang Han; Bin Zhang; Ana Suely Cunha; Sérgio Mota-Rolim; Damien Léger; Kentaro Matsui; Colin A Espie; Frances Chung; Charles M Morin; Mariusz Sieminski; Penzel Thomas; Brigitte Holzinger; Markku Partinen; Yun Kwok Wing Journal: J Sleep Res Date: 2022-04-26 Impact factor: 5.296