Kensuke Kudou1, Hiroshi Saeki2, Yuichiro Nakashima3, Shun Sasaki3, Tomoko Jogo3, Kosuke Hirose3, Qingjiang Hu3, Yasuo Tsuda3, Koichi Kimura1, Ryota Nakanishi3, Nobuhide Kubo3, Koji Ando3, Eiji Oki3, Tetsuo Ikeda1, Yoshihiko Maehara4. 1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Endoscopy and Endoscopic Surgery, Fukuoka Dental College, Fukuoka, Japan. 2. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: h-saeki@surg2.med.kyushu-u.ac.jp. 3. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 4. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Surgery, Kyushu Central Hospital, Fukuoka, Japan.
Abstract
BACKGROUND: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). METHODS: Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. RESULTS: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). CONCLUSIONS: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.
BACKGROUND: There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC). METHODS:Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed. RESULTS: The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P = 0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P = 0.0237). CONCLUSIONS: Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC.
Authors: Christine Koch; Cornelius Reitz; Teresa Schreckenbach; Katrin Eichler; Natalie Filmann; Salah-Eddin Al-Batran; Thorsten Götze; Stefan Zeuzem; Wolf Otto Bechstein; Thomas Kraus; Jörg Bojunga; Markus Düx; Jörg Trojan; Irina Blumenstein Journal: PLoS One Date: 2019-10-22 Impact factor: 3.240