Mitsuro Chiba1, Kunio Nakane2, Tsuyotoshi Tsuji3, Satoko Tsuda4, Hajime Ishii5, Hideo Ohno6, Kenta Watanabe7, Mai Ito8, Masafumi Komatsu9, Koko Yamada10, Takeshi Sugawara11. 1. Chief of the Inflammatory Bowel Disease Section at Akita City Hospital in Japan. mchiba@m2.gyao.ne.jp. 2. Chief of the Gastroenterology Division at Akita City Hospital in Japan. ac060950@akita-city-hp.jp. 3. Chief of the Gastrointestinal Endoscopy Section at Akita City Hospital in Japan. ac070289@akita-city-hp.jp. 4. Gastroenterologist at Akita City Hospital in Japan. satokotsuda07@gmail.com. 5. Gastroenterologist at Akita City Hospital in Japan. acd00377@akita-city-hp.jp. 6. Gastroenterologist at Akita City Hospital in Japan. ac120502@akita-city-hp.jp. 7. Gastroenterologist at Akita City Hospital in Japan. nabeken_9989@yahoo.co.jp. 8. Gastroenterologist at Akita City Hospital in Japan. pixmon1231@gmail.com. 9. Gastroenterologist and the Director of Akita City Hospital in Japan. ac990892@akita-city-hp.jp. 10. Registered Nutritionist at Akita City Hospital in Japan. ac940623@city.akita.akita.jp. 11. Gastroenterologist at Nakadori General Hospital in Japan. nrp05157@nifty.com.
Abstract
CONTEXT: No known published study has focused on a plant-based diet (PBD) in the treatment of ulcerative colitis (UC). OBJECTIVE: To investigate relapse prevention in UC after consumption of a PBD during educational hospitalization in Japan. DESIGN: Prospective study of patients with mild UC or UC in remission who did not need immediate treatment. A PBD and dietary guidance were provided during a two-week hospitalization. MAIN OUTCOME MEASURES: The primary end point was relapse (a flare-up that required more aggressive treatment) during the follow-up period. Kaplan-Meier analysis was used to calculate the cumulative relapse rate. Secondary end points were immediate improvement in symptoms or laboratory data during hospitalization and a chronologic change in the PBD score, which evaluated adherence to the PBD. RESULTS: Sixty cases were studied: 29 initial episode cases and 31 relapse cases. Of these, 31 involved proctitis; 7, left-sided colitis; and 22, extensive colitis. Thirty-seven patients were receiving medication; 23 were not. The median age was 34 years; median follow-up was 3 years 6 months. Eight cases relapsed during follow-up. The cumulative relapse rates at 1, 2, 3, 4, and 5 years of follow-up were 2%, 4%, 7%, 19%, and 19%, respectively. Most patients (77%) experienced some improvement such as disappearance or decrease of bloody stool during hospitalization. The short- and long-term PBD scores after the hospitalization were higher than baseline PBD scores. CONCLUSION: Relapse rates after educational hospitalization providing a PBD were far lower than those reported with medication. Educational hospitalization is effective at inducing habitual dietary changes.
CONTEXT: No known published study has focused on a plant-based diet (PBD) in the treatment of ulcerative colitis (UC). OBJECTIVE: To investigate relapse prevention in UC after consumption of a PBD during educational hospitalization in Japan. DESIGN: Prospective study of patients with mild UC or UC in remission who did not need immediate treatment. A PBD and dietary guidance were provided during a two-week hospitalization. MAIN OUTCOME MEASURES: The primary end point was relapse (a flare-up that required more aggressive treatment) during the follow-up period. Kaplan-Meier analysis was used to calculate the cumulative relapse rate. Secondary end points were immediate improvement in symptoms or laboratory data during hospitalization and a chronologic change in the PBD score, which evaluated adherence to the PBD. RESULTS: Sixty cases were studied: 29 initial episode cases and 31 relapse cases. Of these, 31 involved proctitis; 7, left-sided colitis; and 22, extensive colitis. Thirty-seven patients were receiving medication; 23 were not. The median age was 34 years; median follow-up was 3 years 6 months. Eight cases relapsed during follow-up. The cumulative relapse rates at 1, 2, 3, 4, and 5 years of follow-up were 2%, 4%, 7%, 19%, and 19%, respectively. Most patients (77%) experienced some improvement such as disappearance or decrease of bloody stool during hospitalization. The short- and long-term PBD scores after the hospitalization were higher than baseline PBD scores. CONCLUSION: Relapse rates after educational hospitalization providing a PBD were far lower than those reported with medication. Educational hospitalization is effective at inducing habitual dietary changes.
Authors: Fernando Magro; Andreia Rodrigues; Ana Isabel Vieira; Francisco Portela; Isabelle Cremers; José Cotter; Luis Correia; Maria Antónia Duarte; Maria Lourdes Tavares; Paula Lago; Paula Ministro; Paula Peixe; Susana Lopes; Elizabeth Benito Garcia Journal: Inflamm Bowel Dis Date: 2011-07-26 Impact factor: 5.325
Authors: Mahesh S Desai; Anna M Seekatz; Nicole M Koropatkin; Nobuhiko Kamada; Christina A Hickey; Mathis Wolter; Nicholas A Pudlo; Sho Kitamoto; Nicolas Terrapon; Arnaud Muller; Vincent B Young; Bernard Henrissat; Paul Wilmes; Thaddeus S Stappenbeck; Gabriel Núñez; Eric C Martens Journal: Cell Date: 2016-11-17 Impact factor: 41.582
Authors: Gary D Wu; Jun Chen; Christian Hoffmann; Kyle Bittinger; Ying-Yu Chen; Sue A Keilbaugh; Meenakshi Bewtra; Dan Knights; William A Walters; Rob Knight; Rohini Sinha; Erin Gilroy; Kernika Gupta; Robert Baldassano; Lisa Nessel; Hongzhe Li; Frederic D Bushman; James D Lewis Journal: Science Date: 2011-09-01 Impact factor: 47.728