Literature DB >> 2999707

DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters.

M A Dalrymple, D J McGeoch, A J Davison, C M Preston.   

Abstract

Previous work has shown that transcriptional activation of herpes simplex virus type 1 (HSV-1) immediate early genes is mediated by a protein species (Vmw65) present in the tegument of infecting virions. This paper describes DNA sequence analysis and mRNA mapping of the Vmw65 gene in HSV-1 strain 17. The Vmw65 coding region was identified as a 490 codon sequence encoding a polypeptide of molecular weight 54,342 and characterised by a high proportion of charged amino acid residues. A homologue to Vmw65 was detected in the genome of varicella-zoster virus, another human herpesvirus. Apart from its role in trans-activation, Vmw65 is a major constituent of the virion. Its possible significance in virus structure is discussed.

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Year:  1985        PMID： 2999707      PMCID： PMC322092          DOI： 10.1093/nar/13.21.7865

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  60 in total

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Authors:  P WILDY; W C RUSSELL; R W HORNE
Journal:  Virology       Date:  1960-10       Impact factor: 3.616

2.  Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

Authors:  P C Jones; B Roizman
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

3.  Physical mapping of herpes simplex virus-induced polypeptides.

Authors:  H S Marsden; N D Stow; V G Preston; M C Timbury; N M Wilkie
Journal:  J Virol       Date:  1978-11       Impact factor: 5.103

4.  Restricted transcription of the herpes simplex virus genome occurring early after infection and in the presence of metabolic inhibitors.

Authors:  R I Swanstrom; K Pivo; E K Wagner
Journal:  Virology       Date:  1975-07       Impact factor: 3.616

5.  The cell-free synthesis of herpesvirus-induced polypeptides.

Authors:  C M Preston
Journal:  Virology       Date:  1977-05-01       Impact factor: 3.616

6.  Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome.

Authors:  J B Clements; R J Watson; N M Wilkie
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

7.  Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK.

Authors:  C M Preston
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

8.  Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

Authors:  R W Honess; B Roizman
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

9.  Herpes simplex virus DNA.

Authors:  Y Becker; H Dym; I Sarov
Journal:  Virology       Date:  1968-10       Impact factor: 3.616

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  57 in total

1.  Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 renders expression of the immediate-early genes almost entirely dependent on ICP0.

Authors:  K L Mossman; J R Smiley
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions.

Authors:  M Hagmann; O Georgiev; W Schaffner
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 produces a phenotype similar to that of the in1814 linker insertion mutation.

Authors:  J R Smiley; J Duncan
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

4.  Differences in determinants required for complex formation and transactivation in related VP16 proteins.

Authors:  M Grapes; P O'Hare
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

5.  The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.

Authors:  A Buijs; L van Rompaey; A C Molijn; J N Davis; A C Vertegaal; M D Potter; C Adams; S van Baal; E C Zwarthoff; M F Roussel; G C Grosveld
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

6.  Chemical-inducible, ecdysone receptor-based gene expression system for plants.

Authors:  Malla Padidam; Michael Gore; D Lily Lu; Olga Smirnova
Journal:  Transgenic Res       Date:  2003-02       Impact factor: 2.788

7.  Role of alpha-transinducing factor (VP16) in the induction of alpha genes within the context of viral genomes.

Authors:  D Spector; F Purves; B Roizman
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

8.  A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.

Authors:  P Xiao; J P Capone
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

9.  Enhanced infectivity of herpes simplex virus type 1 viral DNA in a cell line expressing the trans-inducing factor Vmw65.

Authors:  G Werstuck; P Bilan; J P Capone
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

10.  Aryl hydrocarbon receptor (AhR)-mediated reporter gene expression systems in transgenic tobacco plants.

Authors:  Susumu Kodama; Kumiko Okada; Hideyuki Inui; Hideo Ohkawa
Journal:  Planta       Date:  2007-09-19       Impact factor: 4.116
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