OBJECTIVE: Nonrigid image registration with high accuracy and efficiency remains a challenging task for medical image analysis. In this paper, we present the spatially region-weighted correlation ratio (SRWCR) as a novel similarity measure to improve the registration performance. METHODS: SRWCR is rigorously deduced from a three-dimension joint probability density function combining the intensity channels with an extra spatial information channel. SRWCR estimates the optimal functional dependence between the intensities for each spatial bin, in which the spatial distribution modeled by a cubic B-spline function is used to differentiate the contribution of voxels. We also analytically derive the gradient of SRWCR with respect to the transformation parameters and optimize it using a quasi-Newton approach. Furthermore, we propose a GPU-based parallel mechanism to accelerate the computation of SRWCR and its derivatives. RESULTS: The experiments on synthetic images, public four-dimensional thoracic computed tomography (CT) dataset, retinal optical coherence tomography data, and clinical CT and positron emission tomography images confirm that SRWCR significantly outperforms some state-of-the-art techniques such as spatially encoded mutual information and Robust PaTch-based cOrrelation Ration. CONCLUSION: This study demonstrates the advantages of SRWCR in tackling the practical difficulties due to distinct intensity changes, serious speckle noise, or different imaging modalities. SIGNIFICANCE: The proposed registration framework might be more reliable to correct the nonrigid deformations and more potential for clinical applications.
OBJECTIVE: Nonrigid image registration with high accuracy and efficiency remains a challenging task for medical image analysis. In this paper, we present the spatially region-weighted correlation ratio (SRWCR) as a novel similarity measure to improve the registration performance. METHODS: SRWCR is rigorously deduced from a three-dimension joint probability density function combining the intensity channels with an extra spatial information channel. SRWCR estimates the optimal functional dependence between the intensities for each spatial bin, in which the spatial distribution modeled by a cubic B-spline function is used to differentiate the contribution of voxels. We also analytically derive the gradient of SRWCR with respect to the transformation parameters and optimize it using a quasi-Newton approach. Furthermore, we propose a GPU-based parallel mechanism to accelerate the computation of SRWCR and its derivatives. RESULTS: The experiments on synthetic images, public four-dimensional thoracic computed tomography (CT) dataset, retinal optical coherence tomography data, and clinical CT and positron emission tomography images confirm that SRWCR significantly outperforms some state-of-the-art techniques such as spatially encoded mutual information and Robust PaTch-based cOrrelation Ration. CONCLUSION: This study demonstrates the advantages of SRWCR in tackling the practical difficulties due to distinct intensity changes, serious speckle noise, or different imaging modalities. SIGNIFICANCE: The proposed registration framework might be more reliable to correct the nonrigid deformations and more potential for clinical applications.