Tetiana I Bogdanova1,2, Vladimir A Saenko2, Alina V Brenner3, Liudmyla Yu Zurnadzhy1, Tatiana I Rogounovitch4, Ilya A Likhtarov5, Sergii V Masiuk5, Leonila M Kovgan5, Victor M Shpak6, Geraldine A Thomas7, Stephen J Chanock3, Kiyohiko Mabuchi3, Mykola D Tronko8, Shunichi Yamashita2,4. 1. 1 Laboratory of Morphology of Endocrine System, State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine," Kiev , Ukraine . 2. 2 Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan . 3. 3 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, Maryland. 4. 4 Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan . 5. 5 Department of Dosimetry and Radiation Protection, State Institution "National Research Center for Radiation Medicine of NAMS of Ukraine," Kiev, Ukraine . 6. 6 Department of Medical Consequences of the Chernobyl Accident and International Cooperation, State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine," Kiev , Ukraine . 7. 7 Imperial College, Charing Cross Hospital , London, United Kingdom . 8. 8 Department of Fundamental and Applied Problems of Endocrinology, State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine," Kiev , Ukraine .
Abstract
BACKGROUND: The issue of whether radiation-induced thyroid cancer is pathologically different from sporadic remains not fully answered. This study compared structural characteristics and invasive features of papillary thyroid carcinoma (PTC) in two age-matched groups: patients who were children (≤4 years old) at the time of the Chernobyl accident and who lived in three regions of Ukraine most contaminated by radioactive iodine 131I ("radiogenic" cancer), and those who lived in the same regions but who were born after 1987 and were not exposed to 131I ("sporadic" cancer). Further, the histopathologic features of PTC were analyzed in relation to age and individual 131I thyroid dose. METHODS: The study included 301 radiogenic and 194 sporadic PTCs. According to age at surgery, patients were subdivided into children (≤14 years old), adolescents (15-18 years old), and adults (19-28 years old). Statistical analyses included univariate tests and multivariable logistic regression within and across the age subgroups. Analyses of morphological features related to 131I doses were conducted among exposed patients on categorical and continuous scales controlling for sex and age. RESULTS: Among children, radiogenic PTC displayed a significantly higher frequency of tumors with a dominant solid growth pattern, intrathyroidal spread, extrathyroidal extension, lymphatic/vascular invasion, and distant metastases. Exposed adolescents more frequently displayed extrathyroidal extension, lymphatic/vascular invasion, and distant metastases. Exposed adults more frequently had intrathyroidal spread and extrathyroidal extension. The frequency of PTC with dominant papillary pattern and oxyphilic cell metaplasia was significantly lower in radiogenic compared to sporadic tumors for all age groups. Manifestations of tumor aggressiveness were most frequent in children compared to adolescents and adults regardless of etiology. CONCLUSIONS: Radiogenic PTC is less likely to demonstrate a dominant papillary growth pattern and more likely to display more aggressive tumor behavior than sporadic PTC. Histopathologic tumor aggressiveness declines with patient age in both radiogenic and sporadic cases.
BACKGROUND: The issue of whether radiation-induced thyroid cancer is pathologically different from sporadic remains not fully answered. This study compared structural characteristics and invasive features of papillary thyroid carcinoma (PTC) in two age-matched groups: patients who were children (≤4 years old) at the time of the Chernobyl accident and who lived in three regions of Ukraine most contaminated by radioactive iodine131I ("radiogenic" cancer), and those who lived in the same regions but who were born after 1987 and were not exposed to 131I ("sporadic" cancer). Further, the histopathologic features of PTC were analyzed in relation to age and individual 131I thyroid dose. METHODS: The study included 301 radiogenic and 194 sporadic PTCs. According to age at surgery, patients were subdivided into children (≤14 years old), adolescents (15-18 years old), and adults (19-28 years old). Statistical analyses included univariate tests and multivariable logistic regression within and across the age subgroups. Analyses of morphological features related to 131I doses were conducted among exposed patients on categorical and continuous scales controlling for sex and age. RESULTS: Among children, radiogenic PTC displayed a significantly higher frequency of tumors with a dominant solid growth pattern, intrathyroidal spread, extrathyroidal extension, lymphatic/vascular invasion, and distant metastases. Exposed adolescents more frequently displayed extrathyroidal extension, lymphatic/vascular invasion, and distant metastases. Exposed adults more frequently had intrathyroidal spread and extrathyroidal extension. The frequency of PTC with dominant papillary pattern and oxyphilic cell metaplasia was significantly lower in radiogenic compared to sporadic tumors for all age groups. Manifestations of tumor aggressiveness were most frequent in children compared to adolescents and adults regardless of etiology. CONCLUSIONS: Radiogenic PTC is less likely to demonstrate a dominant papillary growth pattern and more likely to display more aggressive tumor behavior than sporadic PTC. Histopathologic tumor aggressiveness declines with patient age in both radiogenic and sporadic cases.
Authors: G A Thomas; E D Williams; D V Becker; T I Bogdanova; E P Demidchik; E Lushnikov; S Nagataki; V Ostapenko; A Pinchera; G Souchkevitch; M D Tronko; A F Tsyb; M Tuttle; S Yamashita Journal: Thyroid Date: 2000-12 Impact factor: 6.568
Authors: Mikhail Fridman; Alfred King-Yin Lam; Olga Krasko; Kurt Werner Schmid; Daniel Igor Branovan; Yuri Demidchik Journal: Exp Mol Pathol Date: 2015-04-01 Impact factor: 3.362
Authors: I Likhtarov; G Thomas; L Kovgan; S Masiuk; M Chepurny; O Ivanova; V Gerasymenko; M Tronko; T Bogdanova; A Bouville Journal: Radiat Prot Dosimetry Date: 2013-04-17 Impact factor: 0.972
Authors: M D Tronko; T I Bogdanova; I V Komissarenko; O V Epstein; V Oliynyk; A Kovalenko; I A Likhtarev; I Kairo; S B Peters; V A LiVolsi Journal: Cancer Date: 1999-07-01 Impact factor: 6.860
Authors: I A Likhtarev; B G Sobolev; I A Kairo; N D Tronko; T I Bogdanova; V A Oleinic; E V Epshtein; V Beral Journal: Nature Date: 1995-06-01 Impact factor: 49.962
Authors: V A LiVolsi; A A Abrosimov; T Bogdanova; G Fadda; J L Hunt; M Ito; J Rosai; G A Thomas; E D Williams Journal: Clin Oncol (R Coll Radiol) Date: 2011-02-18 Impact factor: 4.126
Authors: E Dillwyn Williams; Alexander Abrosimov; Tatiana Bogdanova; Evgeny P Demidchik; Masahiro Ito; Virginia LiVolsi; Evgeny Lushnikov; Juan Rosai; Mikola D Tronko; Anatoly F Tsyb; Sarah L Vowler; Geraldine A Thomas Journal: Thyroid Date: 2008-08 Impact factor: 6.568
Authors: Valentin A Stezhko; Elena E Buglova; Larissa I Danilova; Valentina M Drozd; Nikolaj A Krysenko; Nadia R Lesnikova; Victor F Minenko; Vladislav A Ostapenko; Sergey V Petrenko; Olga N Polyanskaya; Valery A Rzheutski; Mykola D Tronko; Olga O Bobylyova; Tetyana I Bogdanova; Ovsiy V Ephstein; Iryna A Kairo; Olexander V Kostin; Ilya A Likhtarev; Valentin V Markov; Valery A Oliynik; Viktor M Shpak; Valeriy P Tereshchenko; Galina A Zamotayeva; Gilbert W Beebe; Andre C Bouville; Aaron B Brill; John D Burch; Daniel J Fink; Ellen Greenebaum; Geoffrey R Howe; Nickolas K Luckyanov; Ihor J Masnyk; Robert J McConnell; Jacob Robbins; Terry L Thomas; Paul G Voillequé; Lydia B Zablotska Journal: Radiat Res Date: 2004-04 Impact factor: 2.841