In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.
In the presence of a neutral dppf-modified n class="Chemical">iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.
Authors: Seung Wook Kim; Leyah A Schwartz; Jason R Zbieg; Craig E Stivala; Michael J Krische Journal: J Am Chem Soc Date: 2018-12-20 Impact factor: 15.419
Authors: Evan P Vanable; Jennifer L Kennemur; Leo A Joyce; Rebecca T Ruck; Danielle M Schultz; Kami L Hull Journal: J Am Chem Soc Date: 2019-01-07 Impact factor: 15.419