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Literature DB >> 299881

Hematopoietic thymocyte precursors: II. Properties of the precursors.

Abstract

The properties of hematopoietic cells which serve as the precursors of cortical thymocytes in irradiated reconstituted mice have been described. These cells have been termed "prothymocytes." They are 10- to 15-mum diameter cells of low buoyant density. They are nonadherent to glass wool and more resistant to the lytic effects of steroids and gamma-irradiation than their progeny. They lack detectable amounts of the surface markers associated with either B or T cells but do bear at least two antigens recognized by antisera to mouse brain.

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Year: 1977 PMID： 299881 PMCID： PMC2180602 DOI： 10.1084/jem.145.2.405

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

46 in total

1. Selective retention of T cell precursors in bone marrow. Cell populations after filtration through anti-immunoglobulin columns.

Authors: B Rubin; L Trier; B Hertel-Wulff; B Rumler
Journal: Cell Immunol Date: 1975-04 Impact factor: 4.868

9. Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.

Authors: F L Owen
Journal: J Exp Med Date: 1983-02-01 Impact factor: 14.307

10. Human prothymocytes. Membrane properties, differentiation patterns, glucocorticoid sensitivity, and ultrastructural features.

Authors: U Galili; A Polliack; E Okon; R Leizerovitz; H Gamliel; A Korkesh; J G Schenkar; G Izak
Journal: J Exp Med Date: 1980-10-01 Impact factor: 14.307

Hematopoietic thymocyte precursors: II. Properties of the precursors.

1. Selective retention of T cell precursors in bone marrow. Cell populations after filtration through anti-immunoglobulin columns.

2. Differentiation of B lymphocytes from stem cell precursors.

3. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo.

4. Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.

5. Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers.

6. Variations among sublines of inbred AKR mice.

7. Purification of the Thy-1 molecule, a major cell-surface glycoprotein of rat thymocytes.

8. Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

9. Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.

10. A quantitative assay for the progenitors of bone marrow-associated lymphocytes.

1. Cells reacting with the monoclonal anti-IL-2 receptor antibody AMT-13 in the regenerating thymus of irradiated mice.

2. Embryonic mouse thymus development: stem cell entry and differentiation.

Review 3. Maturation of the immune system and immunodeficiency.

4. Prothymocytes as target cells of T cell leukemogenesis in the mouse.

Review 5. Phenotypic and genotypic characteristics of the human prothymocyte.

6. Maturation of mitogenic response in foetal guinea-pig.

7. Characterization of Thy 1.2 positive cells in mouse bone marrow by sedimentation and mitogen stimulation.

8. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.

9. Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.

10. Human prothymocytes. Membrane properties, differentiation patterns, glucocorticoid sensitivity, and ultrastructural features.