L Stapersma1, G van den Brink2, E M Szigethy3, J C Escher2, E M W J Utens1,4,5. 1. Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. 2. Department of Paediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. 3. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. 4. Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands. 5. Academic Center for Child Psychiatry the Bascule/Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND: The co-existence of psychological problems and paediatric inflammatory bowel disease (IBD) is receiving increasing attention. Most studies investigated anxiety and depression, with prevalence rates varying from 0% to 50%. A systematic review is necessary to provide clear insight into the prevalence of anxiety and depression in paediatric IBD. AIM: To systematically evaluate available data on the prevalence of anxiety and depressive symptoms and disorders in paediatric IBD (aged 6-18 years). METHODS: Comprehensive searches were performed in Embase, Medline Ovid, Web of Science, Cochrane, PubMed, PsychInfo Ovid, and Google scholar for studies published from 1994 to 2017. Pooled prevalence rates were calculated using inverse variance heterogeneity models. Meta-regression was used to study if disease type, disease activity and gender influence prevalence. RESULTS: Twenty-eight studies (N = 8107, mean age: 14.3) were identified. Pooled prevalence estimates were 16.4% (95% confidence interval [CI] 6.8%-27.3%) for anxiety symptoms and 4.2% (95% CI 3.6%-4.8%) for anxiety disorders. Pooled prevalence estimates were 15.0% (95% CI 6.4%-24.8%) for depressive symptoms and 3.4% (95% CI 0%-9.3%) for depressive disorders. Meta-regression showed no influence of disease type or gender on these prevalence rates, but studies with a higher percentage of active disease had a higher rate of depressive symptoms. CONCLUSIONS: The described pooled prevalence of anxiety and depressive symptoms is lower than in adult IBD. However, due to varying instruments/cut-offs for measuring symptoms and few studies investigating disorders, the results should be interpreted with caution. Cross-cultural use of the same instruments is needed to gain better insight into prevalence rates.
BACKGROUND: The co-existence of psychological problems and paediatric inflammatory bowel disease (IBD) is receiving increasing attention. Most studies investigated anxiety and depression, with prevalence rates varying from 0% to 50%. A systematic review is necessary to provide clear insight into the prevalence of anxiety and depression in paediatric IBD. AIM: To systematically evaluate available data on the prevalence of anxiety and depressive symptoms and disorders in paediatric IBD (aged 6-18 years). METHODS: Comprehensive searches were performed in Embase, Medline Ovid, Web of Science, Cochrane, PubMed, PsychInfo Ovid, and Google scholar for studies published from 1994 to 2017. Pooled prevalence rates were calculated using inverse variance heterogeneity models. Meta-regression was used to study if disease type, disease activity and gender influence prevalence. RESULTS: Twenty-eight studies (N = 8107, mean age: 14.3) were identified. Pooled prevalence estimates were 16.4% (95% confidence interval [CI] 6.8%-27.3%) for anxiety symptoms and 4.2% (95% CI 3.6%-4.8%) for anxiety disorders. Pooled prevalence estimates were 15.0% (95% CI 6.4%-24.8%) for depressive symptoms and 3.4% (95% CI 0%-9.3%) for depressive disorders. Meta-regression showed no influence of disease type or gender on these prevalence rates, but studies with a higher percentage of active disease had a higher rate of depressive symptoms. CONCLUSIONS: The described pooled prevalence of anxiety and depressive symptoms is lower than in adult IBD. However, due to varying instruments/cut-offs for measuring symptoms and few studies investigating disorders, the results should be interpreted with caution. Cross-cultural use of the same instruments is needed to gain better insight into prevalence rates.
Authors: Tiffany H Taft; Alyse Bedell; Meredith R Craven; Livia Guadagnoli; Sarah Quinton; Stephen B Hanauer Journal: Inflamm Bowel Dis Date: 2019-08-20 Impact factor: 5.325
Authors: Grace K Cushman; Sharon Shih; Mary Gray Stolz; Rebecca C Hinrichs; Tanja Jovanovic; Jennifer L Lee; Subra Kugathasan; Bonney Reed Journal: J Psychosom Res Date: 2020-11-30 Impact factor: 3.006
Authors: Luuk Stapersma; Gertrude van den Brink; Jan van der Ende; Alexander G Bodelier; Herbert M van Wering; Pamela C W M Hurkmans; M Luisa Mearin; Andrea E van der Meulen-de Jong; Johanna C Escher; Elisabeth M W J Utens Journal: Int J Behav Med Date: 2019-08
Authors: Anava A Wren; Nicole Neiman; Thomas J Caruso; Samuel Rodriguez; Katherine Taylor; Martine Madill; Hal Rives; Linda Nguyen Journal: Children (Basel) Date: 2021-05-05
Authors: Erica J Brenner; Millie D Long; Courtney M Mann; Li Lin; Wenli Chen; Camila Reyes; Kirsten M Bahnson; Bryce B Reeve; Michael D Kappelman Journal: Inflamm Bowel Dis Date: 2022-05-04 Impact factor: 7.290
Authors: Gertrude van den Brink; Luuk Stapersma; Anna Sophia Bom; Dimitris Rizopolous; C Janneke van der Woude; Rogier J L Stuyt; Danielle M Hendriks; Joyce A T van der Burg; Ruud Beukers; Thea A Korpershoek; Sabine D M Theuns-Valks; Elisabeth M W J Utens; Johanna C Escher Journal: Inflamm Bowel Dis Date: 2019-11-14 Impact factor: 5.325