Literature DB >> 2998354

Activated c-raf gene in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

F Ishikawa, F Takaku, M Ochiai, K Hayashi, S Hirohashi, M Terada, S Takayama, M Nagao, T Sugimura.   

Abstract

A rat hepatocellular carcinoma, IQ7, induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) gave two transformants of NIH 3T3 cells on DNA mediated gene transfer. One of these transformants was examined further and secondary and tertiary transformants were obtained. The secondary transformant was tumorigenic in nude mice. The activated oncogene in this primary transformant was identified as rat c-raf by Southern blot analysis.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2998354     DOI： 10.1016/0006-291x(85)91005-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Regulation of RAF protein kinases in ERK signalling.

Authors:  Hugo Lavoie; Marc Therrien
Journal:  Nat Rev Mol Cell Biol       Date:  2015-05       Impact factor: 94.444

2.  Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

Authors:  V P Stanton; D W Nichols; A P Laudano; G M Cooper
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

3.  Activation of human c-raf-1 by replacing the N-terminal region with different sequences.

Authors:  T Tahira; M Ochiai; K Hayashi; M Nagao; T Sugimura
Journal:  Nucleic Acids Res       Date:  1987-06-25       Impact factor: 16.971

4.  Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences.

Authors:  V P Stanton; G M Cooper
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272

Review 5.  Human cancer and cellular oncogenes.

Authors:  S Nishimura; T Sekiya
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

6.  The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus.

Authors:  T W Beck; M Huleihel; M Gunnell; T I Bonner; U R Rapp
Journal:  Nucleic Acids Res       Date:  1987-01-26       Impact factor: 16.971

7.  Activation of rat c-raf during transfection of hepatocellular carcinoma DNA.

Authors:  F Ishikawa; F Takaku; K Hayashi; M Nagao; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

8.  Molecular cloning of an oncogene from a human hepatocellular carcinoma.

Authors:  T Ochiya; A Fujiyama; S Fukushige; I Hatada; K Matsubara
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

9.  Rat c-raf oncogene activation by a rearrangement that produces a fused protein.

Authors:  F Ishikawa; F Takaku; M Nagao; T Sugimura
Journal:  Mol Cell Biol       Date:  1987-03       Impact factor: 4.272
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.