Ahmed Al-Habbaa1, Prashanth Rawla2, Mostafa Ebraheem Morra3, Ahmed Ahmed Abotaha4, Eman Elsayed Sakr5, Mostafa Ahmed Abdo Shehata6, Karim Mohamed Shahin6, Sarah Abdel Mageed7, Nguyen Tien Huy8. 1. Faculty of Medicine, Cardiology Department, Al-Azhar University, Cairo, Egypt. 2. Department of Internal Medicine, SOVAH Heath, Martinsville, VA, USA. 3. Faculty of Medicine, Al-Azhar University, Cairo, Egypt. 4. Faculty of Medicine, Internal Medicine Department, Al-Azhar University, Cairo, Egypt. 5. Faculty of Medicine, Menoufia University, Menoufia, Egypt. 6. Faculty of Medicine, Alexandria University, Alexandria, Egypt. 7. Faculty of Medicine, Internal Medicine Department, Tanta University, Tanta, Egypt. 8. Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Abstract
BACKGROUND: Granulomatosis with polyangiitis (GPA) is a systemic inflammatory condition; however, patients with GPA rarely experience endocardial valve lesions. METHODS: We report a GPA case with tricuspid valve destruction together with a systematic review to highlight the characteristics of all previously reported GPA cases with valvular involvement. RESULTS: Among 36 cases included, the aortic valve was involved in 15 (41.7%) cases while the mitral valve was involved in 9 (25%) subjects. Combined lesion of both aortic and mitral valves was reported in 9 (25%) patients. CONCLUSION: We recommend routine echocardiography examination to rule out any cardiac valve lesion once GPA is suspected.
BACKGROUND:Granulomatosis with polyangiitis (GPA) is a systemic inflammatory condition; however, patients with GPA rarely experience endocardial valve lesions. METHODS: We report a GPA case with tricuspid valve destruction together with a systematic review to highlight the characteristics of all previously reported GPA cases with valvular involvement. RESULTS: Among 36 cases included, the aortic valve was involved in 15 (41.7%) cases while the mitral valve was involved in 9 (25%) subjects. Combined lesion of both aortic and mitral valves was reported in 9 (25%) patients. CONCLUSION: We recommend routine echocardiography examination to rule out any cardiac valve lesion once GPA is suspected.
Authors: Gilles Uijtterhaegen; Laura De Donder; Eline Ameloot; Kristof Lefebvre; Jo Van Dorpe; Michel De Pauw; Katrien François Journal: Eur Heart J Case Rep Date: 2020-10-06