Literature DB >> 2997619

Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal.

H J Cooke, W R Brown, G A Rappold.   

Abstract

Pairing of human X and Y chromosomes during meiosis initiates within the so-called pairing region at the telomeres or the chromosome short arms. Using DNA from the Y chromosome we found sequence homology in the pairing region of the human X and Y chromosomes. This DNA is telomeric, contains repetitive sequences and is highly polymorphic in the population. The polymorphism has allowed family studies which show the sequences are not inherited as though linked to the sex chromosomes. This 'pseudoautosomal' pattern of inheritance points to an obligate recombination in the pairing region of the sex chromosomes during male meiosis.

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Year:  1985        PMID： 2997619     DOI： 10.1038/317687a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  104 in total

1.  Population genetic implications from sequence variation in four Y chromosome genes.

Authors:  P Shen; F Wang; P A Underhill; C Franco; W H Yang; A Roxas; R Sung; A A Lin; R W Hyman; D Vollrath; R W Davis; L L Cavalli-Sforza; P J Oefner
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

2.  Chlamydomonas telomere sequences are A+T-rich but contain three consecutive G-C base pairs.

Authors:  M E Petracek; P A Lefebvre; C D Silflow; J Berman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

3.  Non-specific X linked mental retardation with aphasia exhibiting genetic linkage to chromosomal region Xp11.

Authors:  G N Wilson; C S Richards; K Katz; G S Brookshire
Journal:  J Med Genet       Date:  1992-09       Impact factor: 6.318

4.  Chromosome ends in Chironomus pallidivittatus contain different subfamilies of telomere-associated repeats.

Authors:  M Cohn; J E Edström
Journal:  Chromosoma       Date:  1992-10       Impact factor: 4.316

5.  DNA analyses of XX and XX-hypospadiac males.

Authors:  H Numabe; S Nagafuchi; Y Nakahori; T Tamura; H Kiuchi; M Namiki; N Kohda; Y Fukushima; H Fuse; M Kusano
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

6.  Structural and transcriptional analysis of a human subtelomeric repeat.

Authors:  J F Cheng; C L Smith; C R Cantor
Journal:  Nucleic Acids Res       Date:  1991-01-11       Impact factor: 16.971

Review 7.  A sterile male with 45,X0 and a Y;22 translocation.

Authors:  J Arnemann; S Schnittger; G K Hinkel; E Tolkendorf; J Schmidtke; I Hansmann
Journal:  Hum Genet       Date:  1991-06       Impact factor: 4.132

8.  Pseudoautosomal repeat displays higher variability in blacks than in Caucasians.

Authors:  G A Rappold; A Henke; M Pohlschmid; T H Huisman
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132

9.  Sex reversal in a child with a 46,X,Yp+ karyotype: support for the existence of a gene(s), located in distal Xp, involved in testis formation.

Authors:  T Ogata; J R Hawkins; A Taylor; N Matsuo; J Hata; P N Goodfellow
Journal:  J Med Genet       Date:  1992-04       Impact factor: 6.318

10.  Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n.

Authors:  B Weber; C Collins; C Robbins; R E Magenis; A D Delaney; J W Gray; M R Hayden
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971
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