L B Harrington1, K A Hagan2,3, K J Mukamal4, J H Kang2, J Kim3, M Crous-Bou3,5, S Lindström6,7, E B Rimm1,2,3, C Kabrhel2,8, M K Jensen1,2. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 5. Clinical Research Program, BarcelonaBeta Brain Research Center - Pasqual Maragall Foundation, Barcelona, Spain. 6. Department of Epidemiology, University of Washington, Seattle, WA, USA. 7. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 8. Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Abstract
Essentials The association of moderate alcohol consumption with pulmonary embolism (PE) risk remains unclear. In three large US cohorts, we evaluated the association of alcohol consumption with PE risk. We found no evidence of an association of alcohol consumption amount or frequency with PE risk. Secondary analyses of type and heavy episodic drinking also yielded null findings. SUMMARY: Background Moderate alcohol consumption has been variably associated with hemostatic and fibrinolytic factor levels, but the association between alcohol consumption and the risk of incident pulmonary embolism (PE) remains uncertain. Objective To evaluate alcohol consumption amount and frequency in relation to PE risk. Methods Nurses' Health Study (NHS), NHS II and Health Professionals Follow-Up Study participants free of venous thromboembolism (VTE) at baseline (n = 217 442) reported alcohol consumption by type, quantity and frequency, every 2-4 years. Incident PE cases were identified by self-report and confirmed for participants without cancer. In this cohort study, we used Cox proportional hazards models to estimate multivariable-adjusted hazard ratios (HRs) for PE associated with alcohol consumption amount and, separately, frequency. Secondary analyses evaluated alcohol type and heavy episodic drinking in relation to PE risk, and amount and frequency in relation to medical record-confirmed idiopathic PE and any self-reported VTE risk. Cohort-specific analyses were pooled using random-effects meta-analysis. Results During ≥ 20 years of follow-up, we identified 1939 PE events. We found no strong evidence of an association between PE risk and alcohol consumption amount (pooled HRadj for 5.0-14.9 g day-1 vs. abstention = 0.97 [95% CI, 0.79, 1.20]) or frequency (pooled HRadj for 5-7 drinking days per week vs. abstention = 1.04 [95% CI, 0.88, 1.23]). Secondary analyses of type, heavy episodic drinking, idiopathic PE and VTE also yielded null findings. Conclusions Among three large prospective cohorts of US men and women, we found no evidence of an association between the amount or frequency of alcohol consumption and PE risk.
Essentials The association of moderate alcohol consumption with pulmonary embolism (PE) risk remains unclear. In three large US cohorts, we evaluated the association of alcohol consumption with PE risk. We found no evidence of an association of alcohol consumption amount or frequency with PE risk. Secondary analyses of type and heavy episodic drinking also yielded null findings. SUMMARY: Background Moderate alcohol consumption has been variably associated with hemostatic and fibrinolytic factor levels, but the association between alcohol consumption and the risk of incident pulmonary embolism (PE) remains uncertain. Objective To evaluate alcohol consumption amount and frequency in relation to PE risk. Methods Nurses' Health Study (NHS), NHS II and Health Professionals Follow-Up Study participants free of venous thromboembolism (VTE) at baseline (n = 217 442) reported alcohol consumption by type, quantity and frequency, every 2-4 years. Incident PE cases were identified by self-report and confirmed for participants without cancer. In this cohort study, we used Cox proportional hazards models to estimate multivariable-adjusted hazard ratios (HRs) for PE associated with alcohol consumption amount and, separately, frequency. Secondary analyses evaluated alcohol type and heavy episodic drinking in relation to PE risk, and amount and frequency in relation to medical record-confirmed idiopathic PE and any self-reported VTE risk. Cohort-specific analyses were pooled using random-effects meta-analysis. Results During ≥ 20 years of follow-up, we identified 1939 PE events. We found no strong evidence of an association between PE risk and alcohol consumption amount (pooled HRadj for 5.0-14.9 g day-1 vs. abstention = 0.97 [95% CI, 0.79, 1.20]) or frequency (pooled HRadj for 5-7 drinking days per week vs. abstention = 1.04 [95% CI, 0.88, 1.23]). Secondary analyses of type, heavy episodic drinking, idiopathic PE and VTE also yielded null findings. Conclusions Among three large prospective cohorts of US men and women, we found no evidence of an association between the amount or frequency of alcohol consumption and PE risk.
Authors: Ying Bao; Monica L Bertoia; Elizabeth B Lenart; Meir J Stampfer; Walter C Willett; Frank E Speizer; Jorge E Chavarro Journal: Am J Public Health Date: 2016-07-26 Impact factor: 9.308
Authors: E B Rimm; E L Giovannucci; W C Willett; G A Colditz; A Ascherio; B Rosner; M J Stampfer Journal: Lancet Date: 1991-08-24 Impact factor: 79.321
Authors: K J Mukamal; P P Jadhav; R B D'Agostino; J M Massaro; M A Mittleman; I Lipinska; P A Sutherland; T Matheney; D Levy; P W Wilson; R C Ellison; H Silbershatz; J E Muller; G H Tofler Journal: Circulation Date: 2001-09-18 Impact factor: 29.690
Authors: Brandon Luu; Stephanie Ruderman; Robin Nance; Joseph A C Delaney; Jimmy Ma; Andrew Hahn; Susan R Heckbert; Matthew J Budoff; Kristina Crothers; William C Mathews; Katerina Christopolous; Peter W Hunt; Joseph Eron; Richard Moore; Jeanne Keruly; William B Lober; Greer A Burkholder; Amanda Willig; Geetanjali Chander; Mary E McCaul; Karen Cropsey; Conall O'Cleirigh; Inga Peter; Matthew Feinstein; Judith I Tsui; Sara Lindstroem; Michael Saag; Mari M Kitahata; Heidi M Crane; Lydia N Drumright; Bridget M Whitney Journal: HIV Med Date: 2022-03-28 Impact factor: 3.094
Authors: John Gregson; Stephen Kaptoge; Thomas Bolton; Lisa Pennells; Peter Willeit; Stephen Burgess; Steven Bell; Michael Sweeting; Eric B Rimm; Christopher Kabrhel; Bengt Zöller; Gerd Assmann; Vilmundur Gudnason; Aaron R Folsom; Volker Arndt; Astrid Fletcher; Paul E Norman; Børge G Nordestgaard; Akihiko Kitamura; Bakhtawar K Mahmoodi; Peter H Whincup; Matthew Knuiman; Veikko Salomaa; Christa Meisinger; Wolfgang Koenig; Maryam Kavousi; Henry Völzke; Jackie A Cooper; Toshiharu Ninomiya; Edoardo Casiglia; Beatriz Rodriguez; Yoav Ben-Shlomo; Jean-Pierre Després; Leon Simons; Elizabeth Barrett-Connor; Cecilia Björkelund; Marlene Notdurfter; Daan Kromhout; Jackie Price; Susan E Sutherland; Johan Sundström; Jussi Kauhanen; John Gallacher; Joline W J Beulens; Rachel Dankner; Cyrus Cooper; Simona Giampaoli; Jason F Deen; Agustín Gómez de la Cámara; Lewis H Kuller; Annika Rosengren; Peter J Svensson; Dorothea Nagel; Carlos J Crespo; Hermann Brenner; Juan R Albertorio-Diaz; Robert Atkins; Eric J Brunner; Martin Shipley; Inger Njølstad; Deborah A Lawlor; Yvonne T van der Schouw; Randi Marie Selmer; Maurizio Trevisan; W M Monique Verschuren; Philip Greenland; Sylvia Wassertheil-Smoller; Gordon D O Lowe; Angela M Wood; Adam S Butterworth; Simon G Thompson; John Danesh; Emanuele Di Angelantonio; Tom Meade Journal: JAMA Cardiol Date: 2019-02-01 Impact factor: 14.676