Carolyn Newberry1, Jessica Schucht2. 1. Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, 7th Floor, South Tower, Philadelphia, PA, 19104, USA. carolyn.newberry@uphs.upenn.edu. 2. Department of General Surgery, University of Louisville, 323 East Chestnut Street, Louisville, KY, 40202, USA.
Abstract
PURPOSE OF REVIEW: This review provides a comprehensive overview of the etiology of stress-related mucosal disease, current acid suppression therapy recommendations, and the role enteral nutrition may play in disease prevention. RECENT FINDINGS: Recent literature indicates enteral nutrition may prevent complications of stress-related mucosal disease by increasing splanchnic blood flow, enhancing gastrointestinal motility, and promoting cellular immunity and integrity through local nutrient delivery. Stress-related mucosal disease is a common complication of hospitalization in the critically ill which may lead to overt gastrointestinal bleeding and enhanced mortality. High-risk patients have historically been prescribed acid suppression therapy, though enteral nutrition may also have a role in disease mitigation.
PURPOSE OF REVIEW: This review provides a comprehensive overview of the etiology of stress-related mucosal disease, current acid suppression therapy recommendations, and the role enteral nutrition may play in disease prevention. RECENT FINDINGS: Recent literature indicates enteral nutrition may prevent complications of stress-related mucosal disease by increasing splanchnic blood flow, enhancing gastrointestinal motility, and promoting cellular immunity and integrity through local nutrient delivery. Stress-related mucosal disease is a common complication of hospitalization in the critically ill which may lead to overt gastrointestinal bleeding and enhanced mortality. High-risk patients have historically been prescribed acid suppression therapy, though enteral nutrition may also have a role in disease mitigation.
Authors: Nicole M Palm; Brian McKinzie; Pamela L Ferguson; Emily Chapman; Margaret Dorlon; Evert A Eriksson; Brent Jewett; Stuart M Leon; Alicia R Privette; Samir M Fakhry Journal: J Intensive Care Med Date: 2016-11-11 Impact factor: 3.510
Authors: Patrick R Pfau; Gregory S Cooper; Mark D Carlson; Amitabh Chak; Michael V Sivak; Judith A Gonet; Karen K Boyd; Richard C K Wong Journal: Am J Gastroenterol Date: 2004-03 Impact factor: 10.864
Authors: L F Martin; F V Booth; R G Karlstadt; J H Silverstein; D M Jacobs; J Hampsey; S C Bowman; C A D'Ambrosio; F W Rockhold Journal: Crit Care Med Date: 1993-01 Impact factor: 7.598