Literature DB >> 2996327

Prophylactic versus no brain irradiation in regional small cell lung carcinoma.

H G Seydel, R Creech, M Pagano, O Salazar, P Rubin, J Concannon, P Carbone, M Mohuiddin, C Perez, M Matthews.   

Abstract

Among 104 complete responders entered in a randomized prospective trial of treatments for regional small cell undifferentiated carcinoma of the lung, 52 received prophylactic irradiation of the brain, 3,000 rad in 10 fractions, and 52 did not. The median survivals were 53 and 52 weeks respectively, and the incidences of brain metastases were 5% and 20%. Prophylactic brain irradiation was not associated with significant long-term toxicity.

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Year:  1985        PMID: 2996327     DOI: 10.1097/00000421-198506000-00005

Source DB:  PubMed          Journal:  Am J Clin Oncol        ISSN: 0277-3732            Impact factor:   2.339


  5 in total

Review 1.  A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors.

Authors:  D J Stewart
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

Review 2.  WITHDRAWN: Cranial irradiation for preventing brain metastases of small cell lung cancer in patients in complete remission.

Authors: 
Journal:  Cochrane Database Syst Rev       Date:  2018-02-06

3.  Cranial irradiation in small cell lung cancer.

Authors:  A Gregor
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640

Review 4.  Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis.

Authors:  A P Meert; M Paesmans; T Berghmans; B Martin; C Mascaux; F Vallot; J M Verdebout; J J Lafitte; J P Sculier
Journal:  BMC Cancer       Date:  2001-06-19       Impact factor: 4.430

5.  Treatment of brain metastasis from lung cancer.

Authors:  Alexander Chi; Ritsuko Komaki
Journal:  Cancers (Basel)       Date:  2010-12-15       Impact factor: 6.639

  5 in total

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