Edgar A Samaniego1, Jorge A Roa2, Kaustubh Limaye3, Harold P Adams3. 1. Division of Cerebrovascular Diseases Department of Neurology, Neurosurgery and Radiology, Carver College of Medicine, UIHC Comprehensive Stroke Center, University of Iowa, Iowa City, Iowa. Electronic address: edgarsama@gmail.com. 2. School of Medicine, Universidad San Francisco de Quito, Quito, Ecuador. 3. Division of Cerebrovascular Diseases, Department of Neurology, Carver College of Medicine, UIHC Comprehensive Stroke Center, University of Iowa, Iowa City, Iowa.
Abstract
BACKGROUND: The treatment of acute ischemic stroke due to large vessel occlusion (LVO) has revolutionized in the last decade. We sought to compile the most relevant literature published about the evolution in treating this disabling and fatal disease. METHODS: A literature review of recent studies describing early treatment options like intravenous tissue plasminogen activator to the latest mechanical thrombectomy (MT) techniques was performed. We described in a chronological order the evolution of LVO treatment. RESULTS: Recanalization rates with newer techniques and MT devices approach a 90% of effectiveness. Timely interventions have also resulted in better clinical outcomes with approximately 50% of patient achieving functional independence at 90 days. At least 14 new third generation thrombectomy devices are currently being evaluated in in vitro and clinical studies. CONCLUSIONS: The treatment of LVO with MT is feasible and safe. MT is standard of care in treating acute ischemic stroke due to LVO.
BACKGROUND: The treatment of acute ischemic stroke due to large vessel occlusion (LVO) has revolutionized in the last decade. We sought to compile the most relevant literature published about the evolution in treating this disabling and fatal disease. METHODS: A literature review of recent studies describing early treatment options like intravenous tissue plasminogen activator to the latest mechanical thrombectomy (MT) techniques was performed. We described in a chronological order the evolution of LVO treatment. RESULTS: Recanalization rates with newer techniques and MT devices approach a 90% of effectiveness. Timely interventions have also resulted in better clinical outcomes with approximately 50% of patient achieving functional independence at 90 days. At least 14 new third generation thrombectomy devices are currently being evaluated in in vitro and clinical studies. CONCLUSIONS: The treatment of LVO with MT is feasible and safe. MT is standard of care in treating acute ischemic stroke due to LVO.
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