Literature DB >> 2995981

Adrenergic regulation of gluconeogenesis: possible involvement of two mechanisms of signal transduction in alpha 1-adrenergic action.

J A García-Sáinz, S M Hernández-Sotomayor.   

Abstract

We have previously suggested that the effects of alpha 1-adrenergic agents on hepatocyte metabolism involve two mechanisms: (i) a calcium-independent insulin-sensitive process that is modulated by glucocorticoids and (ii) a calcium-dependent insulin-insensitive process that is modulated by thyroid hormones. We have studied the effect of epinephrine (plus propranolol) on gluconeogenesis from lactate and dihydroxyacetone. It was observed that the adrenergic stimulation of gluconeogenesis from lactate seemed to occur through both mechanisms, whereas when the substrate was dihydroxyacetone the action took place exclusively through the calcium-independent insulin-sensitive process. This effect was absent in hepatocytes from adrenalectomized rats, suggesting that it is modulated by glucocorticoids.

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Year:  1985        PMID： 2995981      PMCID： PMC390759          DOI： 10.1073/pnas.82.20.6727

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  alpha-Adrenergic-mediated accumulation of adenosine 3':5' monophosphate in calcium-depleted hepatocytes.

Authors:  T M Chan; J H Exton
Journal:  J Biol Chem       Date:  1977-12-10       Impact factor: 5.157

2.  Regulation by calcium of hormonal effects on gluconeogenesis.

Authors:  N M Kneer; M J Wagner; H A Lardy
Journal:  J Biol Chem       Date:  1979-12-10       Impact factor: 5.157

3.  Adrenergic receptor of the alpha 1-subtype mediates the activation of the glycogen phosphorylase in normal rat liver.

Authors:  M Aggerbeck; G Guellaen; J Hanoune
Journal:  Biochem Pharmacol       Date:  1980-02-15       Impact factor: 5.858

4.  Effect of insulin on alpha1-adrenergic actions in hepatocytes from euthyroid and hypothyroid rats. Possible involvement of two pathways in alpha1-adrenergic actions.

Authors:  C K Pushpendran; S Corvera; J A García-Sáinz
Journal:  Biochem Biophys Res Commun       Date:  1984-01-30       Impact factor: 3.575

5.  The role of calcium in alpha-adrenergic inactivation of glycogen synthase in rat hepatocytes and its inhibition by insulin.

Authors:  W G Strickland; P F Blackmore; J H Exton
Journal:  Diabetes       Date:  1980-08       Impact factor: 9.461

6.  Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

Authors:  M E Tolbert; A C White; K Aspry; J Cutts; J N Fain
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

7.  Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Reciprocal change in alpha- and beta-adrenergic activation of hepatic glycogen phosphorylase and calcium mobilization in adrenalectomized rats.

Authors:  T M Chan; P F Blackmore; K E Steiner; J H Exton
Journal:  J Biol Chem       Date:  1979-04-10       Impact factor: 5.157

8.  The role of calcium ion as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes.

Authors:  J C Garrison; M K Borland; V A Florio; D A Twible
Journal:  J Biol Chem       Date:  1979-08-10       Impact factor: 5.157

9.  Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions.

Authors:  P D Whitton; L M Rodrigues; D A Hems
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

10.  Alpha 1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes.

Authors:  S Corvera; J A García-Sáinz
Journal:  Eur J Pharmacol       Date:  1981-07-10       Impact factor: 4.432
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  7 in total

1.  Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

Authors:  S Cotecchia; D A Schwinn; R R Randall; R J Lefkowitz; M G Caron; B K Kobilka
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

2.  Interpretation of dose-response curves for luteinizing hormone release by gonadotropin-releasing hormone, related peptides, and leukotriene C4 according to a hormone/receptor/effector model.

Authors:  J Leiser; P M Conn; J J Blum
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

3.  Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells.

Authors:  N J Izzo; C E Seidman; S Collins; W S Colucci
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Subclassification of alpha 1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists.

Authors:  G Hanft; G Gross
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

5.  Modulation of the hepatic alpha 1-adrenoceptor responsiveness by colchicine: dissociation of free cytosolic Ca(2+)-dependent and independent responses.

Authors:  N Butta; A Martin-Requero; E Urcelay; R Parrilla; M S Ayuso
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

Review 6.  Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure.

Authors:  Dianne M Perez
Journal:  Int J Mol Sci       Date:  2021-05-28       Impact factor: 5.923

7.  A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.

Authors:  A Ardati; M Nemer
Journal:  EMBO J       Date:  1993-12-15       Impact factor: 11.598
  7 in total

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