Literature DB >> 2995924

Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin.

J F Burke, A E Mogg.   

Abstract

Aminoglycoside antibiotics in Escherichia coli and yeast can cause ribosomes to read through stop codons during translation. This can result in the phenotypic suppression of nonsense mutations. We show here for the first time that the aminoglycosides G-418 and paromomycin have similar effects in monkey (COS-7) cells in vivo. Suppression of an amber mutation (TAG) by aminoglycosides can restore the activity of a mutant gene transfected into COS-7 cells to almost 20% of wild type levels.

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Year:  1985        PMID： 2995924      PMCID： PMC321951          DOI： 10.1093/nar/13.17.6265

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  STREPTOMYCIN, SUPPRESSION, AND THE CODE.

Authors:  J DAVIES; W GILBERT; L GORINI
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

2.  Phenotypic suppression and misreading Saccharomyces cerevisiae.

Authors:  A Singh; D Ursic; J Davies
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

3.  Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics.

Authors:  E Palmer; J M Wilhelm; F Sherman
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

4.  The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

Authors:  C M Gorman; G T Merlino; M C Willingham; I Pastan; B H Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

5.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

6.  Mistranslation in a eucaryotic organism.

Authors:  E Palmer; J M Wilhelm
Journal:  Cell       Date:  1978-02       Impact factor: 41.582

7.  Aminoglycoside antibiotics and eukaryotic protein synthesis: stimulation of errors in the translation of natural messengers in extracts of cultured human cells.

Authors:  J M Wilhelm; J J Jessop; S E Pettitt
Journal:  Biochemistry       Date:  1978-04-04       Impact factor: 3.162

8.  Aminoglycoside antibiotics and eukaryotic protein synthesis: structure--function relationships in the stimulation of misreading with a wheat embryo system.

Authors:  J M Wilhelm; S E Pettitt; J J Jessop
Journal:  Biochemistry       Date:  1978-04-04       Impact factor: 3.162

9.  beta 0 thalassemia, a nonsense mutation in man.

Authors:  J C Chang; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

10.  beta zero thalassemia in Sardinia is caused by a nonsense mutation.

Authors:  R F Trecartin; S A Liebhaber; J C Chang; K Y Lee; Y W Kan; M Furbetta; A Angius; A Cao
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808
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  75 in total

Review 1.  Correction of genetic disease by making sense from nonsense.

Authors:  R J Kaufman
Journal:  J Clin Invest       Date:  1999-08       Impact factor: 14.808

2.  Aminoglycoside treatment for muscular dystrophy is scientifically rational, but is it clinically effective?

Authors:  Michio Hirano
Journal:  Curr Neurol Neurosci Rep       Date:  2002-01       Impact factor: 5.081

3.  The major 5' determinant in stop codon read-through involves two adjacent adenines.

Authors:  Sanaa Tork; Isabelle Hatin; Jean-Pierre Rousset; Céline Fabret
Journal:  Nucleic Acids Res       Date:  2004-01-21       Impact factor: 16.971

4.  Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.

Authors:  Gabriele Neu-Yilik; Beate Amthor; Niels H Gehring; Sharif Bahri; Helena Paidassi; Matthias W Hentze; Andreas E Kulozik
Journal:  RNA       Date:  2011-03-09       Impact factor: 4.942

Review 5.  Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.

Authors:  William T Harkcom; Geoffrey W Abbott
Journal:  Expert Rev Cardiovasc Ther       Date:  2010-08

6.  The allosuppressor gene SAL4 encodes a protein important for maintaining translational fidelity in Saccharomyces cerevisiae.

Authors:  M Crouzet; F Izgu; C M Grant; M F Tuite
Journal:  Curr Genet       Date:  1988-12       Impact factor: 3.886

7.  Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.

Authors:  Jeyakumar Kandasamy; Dana Atia-Glikin; Eli Shulman; Katya Shapira; Michal Shavit; Valery Belakhov; Timor Baasov
Journal:  J Med Chem       Date:  2012-11-29       Impact factor: 7.446

8.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 9.  Lafora disease - from pathogenesis to treatment strategies.

Authors:  Felix Nitschke; Saija J Ahonen; Silvia Nitschke; Sharmistha Mitra; Berge A Minassian
Journal:  Nat Rev Neurol       Date:  2018-10       Impact factor: 42.937

10.  Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model.

Authors:  Virginia B Mattis; Allison D Ebert; Marina Y Fosso; Cheng-Wei Chang; Christian L Lorson
Journal:  Hum Mol Genet       Date:  2009-07-21       Impact factor: 6.150
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