Literature DB >> 29959193

Translational Control in Cancer.

Nathaniel Robichaud1, Nahum Sonenberg1, Davide Ruggero2, Robert J Schneider3.   

Abstract

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of gene expression. This is especially true in the cancer setting, as many oncogenes and transforming events are regulated at this level. Cancer-promoting factors that are translationally regulated include cyclins, antiapoptotic factors, proangiogenic factors, regulators of cell metabolism, prometastatic factors, immune modulators, and proteins involved in DNA repair. This review discusses the diverse means by which cancer cells deregulate and reprogram translation, and the resulting oncogenic impacts, providing insights into the complexity of translational control in cancer and its targeting for cancer therapy.
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2019        PMID： 29959193      PMCID： PMC6601465          DOI： 10.1101/cshperspect.a032896

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  165 in total

Review 1.  Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.

Authors:  Shima Nakanishi; John L Cleveland
Journal:  Amino Acids       Date:  2016-06-29       Impact factor: 3.520

Review 2.  Nonsense-Mediated mRNA Decay Begins Where Translation Ends.

Authors:  Evangelos D Karousis; Oliver Mühlemann
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-02-01       Impact factor: 10.005

Review 3.  Therapeutic Opportunities in Eukaryotic Translation.

Authors:  Jennifer Chu; Jerry Pelletier
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-06-01       Impact factor: 10.005

Review 4.  The role of eIF3 and its individual subunits in cancer.

Authors:  John W B Hershey
Journal:  Biochim Biophys Acta       Date:  2014-11-01

Review 5.  Cancer syndromes and therapy by stop-codon readthrough.

Authors:  Renata Bordeira-Carriço; Ana Paula Pêgo; Manuel Santos; Carla Oliveira
Journal:  Trends Mol Med       Date:  2012-10-06       Impact factor: 11.951

6.  MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.

Authors:  Jonathan B Bell; Frank D Eckerdt; Kristen Alley; Lisa P Magnusson; Hridi Hussain; Yingtao Bi; Ahmet Dirim Arslan; Jessica Clymer; Angel A Alvarez; Stewart Goldman; Shi-Yuan Cheng; Ichiro Nakano; Craig Horbinski; Ramana V Davuluri; C David James; Leonidas C Platanias
Journal:  Mol Cancer Res       Date:  2016-06-30       Impact factor: 5.852

7.  Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.

Authors:  Sharon Lim; Tzuen Yih Saw; Min Zhang; Matthew R Janes; Kassoum Nacro; Jeffrey Hill; An Qi Lim; Chia-Tien Chang; David A Fruman; David A Rizzieri; Soo Yong Tan; Hung Fan; Charles T H Chuah; S Tiong Ong
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-04       Impact factor: 11.205

8.  Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.

Authors:  Balachandra K Gorentla; Sruti Krishna; Jinwook Shin; Makoto Inoue; Mari L Shinohara; Jason M Grayson; Rikiro Fukunaga; Xiao-Ping Zhong
Journal:  J Immunol       Date:  2012-12-26       Impact factor: 5.422

9.  Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.

Authors:  I B Rosenwald; A Lazaris-Karatzas; N Sonenberg; E V Schmidt
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272

10.  nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Authors:  Valentina Gandin; Laia Masvidal; Laura Hulea; Simon-Pierre Gravel; Marie Cargnello; Shannon McLaughlan; Yutian Cai; Preetika Balanathan; Masahiro Morita; Arjuna Rajakumar; Luc Furic; Michael Pollak; John A Porco; Julie St-Pierre; Jerry Pelletier; Ola Larsson; Ivan Topisirovic
Journal:  Genome Res       Date:  2016-03-16       Impact factor: 9.043
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  66 in total

Review 1.  uORF-mediated translational control: recently elucidated mechanisms and implications in cancer.

Authors:  Hung-Hsi Chen; Woan-Yuh Tarn
Journal:  RNA Biol       Date:  2019-06-24       Impact factor: 4.652

2.  Decapping enzymes STOP "cancer" ribosomes in their tracks.

Authors:  Jeffrey S Mugridge; John D Gross
Journal:  EMBO J       Date:  2018-11-19       Impact factor: 11.598

Review 3.  Phosphorylation and Signal Transduction Pathways in Translational Control.

Authors:  Christopher G Proud
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-07-01       Impact factor: 10.005

Review 4.  The Epitranscriptome in Translation Regulation.

Authors:  Eyal Peer; Sharon Moshitch-Moshkovitz; Gideon Rechavi; Dan Dominissini
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-08-01       Impact factor: 10.005

Review 5.  Ribosome Profiling: Global Views of Translation.

Authors:  Nicholas T Ingolia; Jeffrey A Hussmann; Jonathan S Weissman
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-05-01       Impact factor: 10.005

6.  Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis.

Authors:  Richard Y Ebright; Sooncheol Lee; Ben S Wittner; Kira L Niederhoffer; Benjamin T Nicholson; Aditya Bardia; Samuel Truesdell; Devon F Wiley; Benjamin Wesley; Selena Li; Andy Mai; Nicola Aceto; Nicole Vincent-Jordan; Annamaria Szabolcs; Brian Chirn; Johannes Kreuzer; Valentine Comaills; Mark Kalinich; Wilhelm Haas; David T Ting; Mehmet Toner; Shobha Vasudevan; Daniel A Haber; Shyamala Maheswaran; Douglas S Micalizzi
Journal:  Science       Date:  2020-02-06       Impact factor: 47.728

7.  MNK2 governs the macrophage antiinflammatory phenotype.

Authors:  Margarita Bartish; Dongmei Tong; Yangxun Pan; Majken Wallerius; Hui Liu; Johannes Ristau; Sabrina de Souza Ferreira; Tatjana Wallmann; Vincent van Hoef; Laia Masvidal; Thomas Kerzel; Anne-Laure Joly; Christophe Goncalves; Samuel E J Preston; Talin Ebrahimian; Christina Seitz; Jonas Bergh; Kristian Pietras; Stephanie Lehoux; Luigi Naldini; John Andersson; Mario Leonardo Squadrito; Sonia V Del Rincón; Ola Larsson; Charlotte Rolny
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-19       Impact factor: 11.205

8.  METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Authors:  Shuo Liu; Simone Hausmann; Scott Moore Carlson; Mary Esmeralda Fuentes; Joel William Francis; Renjitha Pillai; Shane Michael Lofgren; Laura Hulea; Kristofferson Tandoc; Jiuwei Lu; Ami Li; Nicholas Dang Nguyen; Marcello Caporicci; Michael Paul Kim; Anirban Maitra; Huamin Wang; Ignacio Ivan Wistuba; John Anthony Porco; Michael Cory Bassik; Joshua Eric Elias; Jikui Song; Ivan Topisirovic; Capucine Van Rechem; Pawel Karol Mazur; Or Gozani
Journal:  Cell       Date:  2019-01-03       Impact factor: 41.582

9.  The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.

Authors:  Xin Jin; Jianling Xie; Michael Zabolocki; Xuemin Wang; Tao Jiang; Dong Wang; Laurent Désaubry; Cedric Bardy; Christopher G Proud
Journal:  J Biol Chem       Date:  2020-05-19       Impact factor: 5.157

10.  RiboDiPA: a novel tool for differential pattern analysis in Ribo-seq data.

Authors:  Keren Li; C Matthew Hope; Xiaozhong A Wang; Ji-Ping Wang
Journal:  Nucleic Acids Res       Date:  2020-12-02       Impact factor: 16.971
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