Craig M Coopersmith1, Daniel De Backer2, Clifford S Deutschman3, Ricard Ferrer4, Ishaq Lat5, Flavia R Machado6, Greg S Martin7, Ignacio Martin-Loeches8, Mark E Nunnally9, Massimo Antonelli10, Laura E Evans11, Judith Hellman12, Sameer Jog13, Jozef Kesecioglu14, Mitchell M Levy15, Andrew Rhodes16. 1. Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA, USA. 2. Chirec Hospitals, Université Libre de Bruxelles, Brussels, Belgium. 3. Department of Pediatrics, Cohen Children's Medical center, Northwell Health, New Hyde Park, NY and the Feinstein Institute for Medical Research/Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USA. 4. Intensive Care Department, Vall d'Hebron University Hospital. 5. Rush University Medical Center, Chicago, IL, USA. 6. Universidade Federal de São Paulo, Sao Paulo, Brazil. 7. Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Grady Memorial Hospital and Emory Critical Care Center, Emory University, Atlanta, GA, USA. 8. Multidisciplinary Intensive Care Research Organization (MICRO), Department of Intensive Care Medicine, St. James's University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland. 9. New York University School of Medicine, New York, NY, USA. 10. Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A.Gemelli-Università Cattolica del Sacro Cuore, Rome, Italy. 11. Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Bellevue Hospital Center and New York University School of Medicine, New York, NY, USA. 12. University of California, San Francisco, San Francisco, California, USA. 13. Consultant Intensivist, Deenanath Mangeshkar Hospital and Research center, Pune, India. 14. Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands. 15. Alpert Medical School at Brown University, Rhode Island Hospital, Providence, Rhode Island, USA. 16. Department of Adult Critical Care, St. George's University Hospitals NHS Foundation Trust and St George's University of London, London, UK.
Abstract
OBJECTIVE: To identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock. DESIGN: A consensus committee of 16 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine was convened at the annual meetings of both societies. Subgroups had teleconference and electronic-based discussion. The entire committee iteratively developed the entire document and recommendations. METHODS: Each committee member independently gave their top five priorities for sepsis research. A total of 88 suggestions (Supplemental Table 1, Supplemental Digital Content 2, http://links.lww.com/CCM/D636) were grouped into categories by the committee co-chairs, leading to the formation of seven subgroups: infection, fluids and vasoactive agents, adjunctive therapy, administration/epidemiology, scoring/identification, post-intensive care unit, and basic/translational science. Each subgroup had teleconferences to go over each priority followed by formal voting within each subgroup. The entire committee also voted on top priorities across all subgroups except for basic/translational science. RESULTS: The Surviving Sepsis Research Committee provides 26 priorities for sepsis and septic shock. Of these, the top six clinical priorities were identified and include the following questions: 1) can targeted/personalized/precision medicine approaches determine which therapies will work for which patients at which times?; 2) what are ideal endpoints for volume resuscitation and how should volume resuscitation be titrated?; 3) should rapid diagnostic tests be implemented in clinical practice?; 4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; 5) what are the predictors of sepsis long-term morbidity and mortality?; and 6) what information identifies organ dysfunction? CONCLUSIONS: While the Surviving Sepsis Campaign guidelines give multiple recommendations on the treatment of sepsis, significant knowledge gaps remain, both in bedside issues directly applicable to clinicians, as well as understanding the fundamental mechanisms underlying the development and progression of sepsis. The priorities identified represent a roadmap for research in sepsis and septic shock.
OBJECTIVE: To identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock. DESIGN: A consensus committee of 16 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine was convened at the annual meetings of both societies. Subgroups had teleconference and electronic-based discussion. The entire committee iteratively developed the entire document and recommendations. METHODS: Each committee member independently gave their top five priorities for sepsis research. A total of 88 suggestions (Supplemental Table 1, Supplemental Digital Content 2, http://links.lww.com/CCM/D636) were grouped into categories by the committee co-chairs, leading to the formation of seven subgroups: infection, fluids and vasoactive agents, adjunctive therapy, administration/epidemiology, scoring/identification, post-intensive care unit, and basic/translational science. Each subgroup had teleconferences to go over each priority followed by formal voting within each subgroup. The entire committee also voted on top priorities across all subgroups except for basic/translational science. RESULTS: The Surviving Sepsis Research Committee provides 26 priorities for sepsis and septic shock. Of these, the top six clinical priorities were identified and include the following questions: 1) can targeted/personalized/precision medicine approaches determine which therapies will work for which patients at which times?; 2) what are ideal endpoints for volume resuscitation and how should volume resuscitation be titrated?; 3) should rapid diagnostic tests be implemented in clinical practice?; 4) should empiric antibiotic combination therapy be used in sepsis or septic shock?; 5) what are the predictors of sepsis long-term morbidity and mortality?; and 6) what information identifies organ dysfunction? CONCLUSIONS: While the Surviving Sepsis Campaign guidelines give multiple recommendations on the treatment of sepsis, significant knowledge gaps remain, both in bedside issues directly applicable to clinicians, as well as understanding the fundamental mechanisms underlying the development and progression of sepsis. The priorities identified represent a roadmap for research in sepsis and septic shock.
Authors: Constantine J. Karvellas; Victor Dong; Juan G. Abraldes; Erica L.W. Lester; Anand Kumar Journal: Can J Surg Date: 2019-06-01 Impact factor: 2.089
Authors: Derek B Danahy; Samarchith P Kurup; Christina S Winborn; Isaac J Jensen; John T Harty; Thomas S Griffith; Vladimir P Badovinac Journal: J Immunol Date: 2019-06-12 Impact factor: 5.422
Authors: Glenn Hernández; Gustavo A Ospina-Tascón; Lucas Petri Damiani; Elisa Estenssoro; Arnaldo Dubin; Javier Hurtado; Gilberto Friedman; Ricardo Castro; Leyla Alegría; Jean-Louis Teboul; Maurizio Cecconi; Giorgio Ferri; Manuel Jibaja; Ronald Pairumani; Paula Fernández; Diego Barahona; Vladimir Granda-Luna; Alexandre Biasi Cavalcanti; Jan Bakker; Glenn Hernández; Gustavo Ospina-Tascón; Lucas Petri Damiani; Elisa Estenssoro; Arnaldo Dubin; Javier Hurtado; Gilberto Friedman; Ricardo Castro; Leyla Alegría; Jean-Louis Teboul; Maurizio Cecconi; Maurizio Cecconi; Giorgio Ferri; Manuel Jibaja; Ronald Pairumani; Paula Fernández; Diego Barahona; Alexandre Biasi Cavalcanti; Jan Bakker; Glenn Hernández; Leyla Alegría; Giorgio Ferri; Nicolás Rodriguez; Patricia Holger; Natalia Soto; Mario Pozo; Jan Bakker; Deborah Cook; Jean-Louis Vincent; Andrew Rhodes; Bryan P Kavanagh; Phil Dellinger; Wim Rietdijk; David Carpio; Nicolás Pavéz; Elizabeth Henriquez; Sebastian Bravo; Emilio Daniel Valenzuela; Magdalena Vera; Jorge Dreyse; Vanessa Oviedo; Maria Alicia Cid; Macarena Larroulet; Edward Petruska; Claudio Sarabia; David Gallardo; Juan Eduardo Sanchez; Hugo González; José Miguel Arancibia; Alex Muñoz; Germán Ramirez; Florencia Aravena; Andrés Aquevedo; Fabián Zambrano; Milan Bozinovic; Felipe Valle; Manuel Ramirez; Victor Rossel; Pilar Muñoz; Carolina Ceballos; Christian Esveile; Cristian Carmona; Eva Candia; Daniela Mendoza; Aída Sanchez; Daniela Ponce; Daniela Ponce; Jaime Lastra; Bárbara Nahuelpán; Fabrizio Fasce; Cecilia Luengo; Nicolas Medel; Cesar Cortés; Luz Campassi; Paolo Rubatto; Nahime Horna; Mariano Furche; Juan Carlos Pendino; Lisandro Bettini; Carlos Lovesio; María Cecilia González; Jésica Rodruguez; Héctor Canales; Francisco Caminos; Cayetano Galletti; Estefanía Minoldo; Maria Jose Aramburu; Daniela Olmos; Nicolás Nin; Jordán Tenzi; Carlos Quiroga; Pablo Lacuesta; Agustín Gaudín; Richard Pais; Ana Silvestre; Germán Olivera; Gloria Rieppi; Dolores Berrutti; Marcelo Ochoa; Paul Cobos; Fernando Vintimilla; Vanessa Ramirez; Milton Tobar; Fernanda García; Fabricio Picoita; Nelson Remache; Vladimir Granda; Fernando Paredes; Eduardo Barzallo; Paul Garcés; Fausto Guerrero; Santiago Salazar; German Torres; Cristian Tana; José Calahorrano; Freddy Solis; Pedro Torres; Luís Herrera; Antonio Ornes; Verónica Peréz; Glenda Delgado; Alexei López; Eliana Espinosa; José Moreira; Blanca Salcedo; Ivonne Villacres; Jhonny Suing; Marco Lopez; Luis Gomez; Guillermo Toctaquiza; Mario Cadena Zapata; Milton Alonso Orazabal; Ruben Pardo Espejo; Jorge Jimenez; Alexander Calderón; Gustavo Paredes; José Luis Barberán; Tatiana Moya; Horacio Atehortua; Rodolfo Sabogal; Guillermo Ortiz; Antonio Lara; Fabio Sanchez; Alvaro Hernán Portilla; Humberto Dávila; Jorge Antonio Mora; Luis Eduardo Calderón; Ingrid Alvarez; Elena Escobar; Alejandro Bejarano; Luis Alfonso Bustamante; José Luis Aldana Journal: JAMA Date: 2019-02-19 Impact factor: 56.272
Authors: Ignacio Martin-Loeches; Massimo Antonelli; Manuel Cuenca-Estrella; George Dimopoulos; Sharon Einav; Jan J De Waele; Jose Garnacho-Montero; Souha S Kanj; Flavia R Machado; Philippe Montravers; Yasser Sakr; Maurizio Sanguinetti; Jean-Francois Timsit; Matteo Bassetti Journal: Intensive Care Med Date: 2019-03-25 Impact factor: 17.440
Authors: Jerry J Zimmerman; Russell Banks; Robert A Berg; Athena Zuppa; Christopher J Newth; David Wessel; Murray M Pollack; Kathleen L Meert; Mark W Hall; Michael Quasney; Anil Sapru; Joseph A Carcillo; Patrick S McQuillen; Peter M Mourani; Hector Wong; Ranjit S Chima; Richard Holubkov; Whitney Coleman; Samuel Sorenson; James W Varni; Julie McGalliard; Wren Haaland; Kathryn Whitlock; J Michael Dean; Ron W Reeder Journal: Crit Care Med Date: 2020-03 Impact factor: 7.598