Robert H Paul1,2, Sarah A Cooley, Paola M Garcia-Egan1, Beau M Ances3,4. 1. Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, MO. 2. Department of Psychological Sciences, Missouri Institute of Mental Health, St. Louis, MO. 3. Radiology. 4. Biomedical Engineering, Washington University in St. Louis, St. Louis, MO.
Abstract
OBJECTIVE: This study examined the relative contribution of cognitive status to frailty among older individuals infected with HIV+. DESIGN: Participants included 122 HIV+ individuals [mean age = 57.5 (6.6)] with a median CD4 cell count of 546. Undetectable viral load (<50 copies per mL) was observed in 94% of the sample. The sample was defined as frail (n = 21) and nonfrail (n = 101) according to the Fried phenotype criteria. Cognitive tests included measures of executive function, motor/psychomotor, language, learning, and memory. Performances were converted to standardized scores and averaged to calculate individual domain scores and a global index of cognitive function. METHODS: Logistic and hierarchical regressions were completed to separately determine the associations between clinical, demographic, and cognitive variables with regards to frailty status. RESULTS: Results of the logistic regressions revealed that lower executive function, female sex, and higher symptoms of depression were associated with frailty. The hierarchical analysis revealed no significant contribution of executive function to frailty status after accounting for female sex and symptoms of depression (Nagelkerke R = 0.15). CONCLUSIONS: These results emphasize the importance of sex distribution and mental health in explanatory models of frailty in HIV. Further, interventions targeting symptoms of depression may increase resilience in older HIV+ individuals.
OBJECTIVE: This study examined the relative contribution of cognitive status to frailty among older individuals infected with HIV+. DESIGN:Participants included 122 HIV+ individuals [mean age = 57.5 (6.6)] with a median CD4 cell count of 546. Undetectable viral load (<50 copies per mL) was observed in 94% of the sample. The sample was defined as frail (n = 21) and nonfrail (n = 101) according to the Fried phenotype criteria. Cognitive tests included measures of executive function, motor/psychomotor, language, learning, and memory. Performances were converted to standardized scores and averaged to calculate individual domain scores and a global index of cognitive function. METHODS: Logistic and hierarchical regressions were completed to separately determine the associations between clinical, demographic, and cognitive variables with regards to frailty status. RESULTS: Results of the logistic regressions revealed that lower executive function, female sex, and higher symptoms of depression were associated with frailty. The hierarchical analysis revealed no significant contribution of executive function to frailty status after accounting for female sex and symptoms of depression (Nagelkerke R = 0.15). CONCLUSIONS: These results emphasize the importance of sex distribution and mental health in explanatory models of frailty in HIV. Further, interventions targeting symptoms of depression may increase resilience in older HIV+ individuals.
Authors: Robert H Paul; Kyu S Cho; Patrick Luckett; Jeremy F Strain; Andrew C Belden; Jacob D Bolzenius; Jaimie Navid; Paola M Garcia-Egan; Sarah A Cooley; Julie K Wisch; Anna H Boerwinkle; Dimitre Tomov; Abel Obosi; Julie A Mannarino; Beau M Ances Journal: J Acquir Immune Defic Syndr Date: 2020-08-01 Impact factor: 3.731
Authors: Robert H Paul; Kyu Cho; Andrew Belden; Adam W Carrico; Eileen Martin; Jacob Bolzenius; Patrick Luckett; Sarah A Cooley; Julie Mannarino; Jodi M Gilman; Mariah Miano; Beau M Ances Journal: J Neuroimmune Pharmacol Date: 2022-01-04 Impact factor: 4.147
Authors: Jessica Robinson-Papp; Gary Gensler; Allison Navis; Seth Sherman; Ronald J Ellis; Benjamin B Gelman; Dennis L Kolson; Scott L Letendre; Elyse J Singer; Miguel Valdes-Sueiras; Susan Morgello Journal: Clin Infect Dis Date: 2020-09-12 Impact factor: 9.079
Authors: Alyssa Vecchio; Gertrude Nakigozi; Noeline Nakasujja; Alice Kisakye; James Batte; Richard Mayanja; Aggrey Anok; Kevin Robertson; Maria J Wawer; Ned Sacktor; Leah H Rubin; Deanna Saylor Journal: J Neurovirol Date: 2021-03-31 Impact factor: 2.643
Authors: Raha M Dastgheyb; Ned Sacktor; Donald Franklin; Scott Letendre; Thomas Marcotte; Robert Heaton; Igor Grant; Justin C McArthur; Leah H Rubin; Norman J Haughey Journal: J Acquir Immune Defic Syndr Date: 2019-09-01 Impact factor: 3.771
Authors: Sarah A Cooley; Jaimie Navid; Julie K Wisch; Anna Boerwinkle; John Doyle; Robert H Paul; Beau M Ances Journal: J Acquir Immune Defic Syndr Date: 2021-07-01 Impact factor: 3.771
Authors: Rafael Antonius Araujo; Sávio Amaral; Arthur Tolentino; Diana Zeballos; Iris Montaño; Lucca S Souza; Liliane Lins-Kusterer; Carlos Brites Journal: AIDS Behav Date: 2021-07-26