Chunlong Li1, Panpan Guo2, Akinkunmi Paul Okekunle2, Xiaoning Ji2, Min Huang2, Jiayue Qi2, Yongshuai Jiang3, Rennan Feng2, Rui Li4. 1. Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. 2. Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, China. 3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China. 4. Dalian Center for Disease Control and Prevention, Dalian, Liaoning Province, China.
Abstract
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that involves a complex interaction between genetics, diet, and lifestyle. Although closely related with obese subjects, it is also common in lean humans. This study aimed to characterize the diet and lifestyle of lean and obese NAFLD patients in China. METHODS: To characterize the diet and lifestyle of lean and obese NAFLD patients, we conducted a matched case-control study that included 351 Chinese adults. General characteristics, dietary intake, and lifestyle were gathered by using a valid and reliable dietary questionnaire. We compared the dietary intake and lifestyle between lean and obese NAFLD patients. RESULTS: All NAFLD patients had more total caloric, calorigenic nutrients (carbohydrate, fat, and protein), grain, potato, fruit, and iron with higher levels of waist circumference and overtime work but shorter sleep duration than their corresponding controls. Particularly, lean NAFLD patients consumed comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLD patients, though they consumed lower levels of grain, potato, and fruit (lean NAFLD patients vs. obese NAFLD patients: mean ± SD, g/day grain: 291.8 ± 83.8, 365.2 ± 89.0; potato: 63.5 ± 33.1, 80.4 ± 37.6; fruit: 324.3 ± 148.4, 414.0 ± 220.4; P < 0.0001). CONCLUSION: Non-alcoholic fatty liver disease patients had higher total caloric, calorigenic nutrients, grain, potato, fruit, iron, and overtime work but shorter sleep duration. Lean NAFLD patients had comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLD patients. These features could be used to the nutritional education and therapeutic guidance for lean NAFLD patients in the future.
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that involves a complex interaction between genetics, diet, and lifestyle. Although closely related with obese subjects, it is also common in lean humans. This study aimed to characterize the diet and lifestyle of lean and obese NAFLDpatients in China. METHODS: To characterize the diet and lifestyle of lean and obese NAFLDpatients, we conducted a matched case-control study that included 351 Chinese adults. General characteristics, dietary intake, and lifestyle were gathered by using a valid and reliable dietary questionnaire. We compared the dietary intake and lifestyle between lean and obese NAFLDpatients. RESULTS: All NAFLD patients had more total caloric, calorigenic nutrients (carbohydrate, fat, and protein), grain, potato, fruit, and iron with higher levels of waist circumference and overtime work but shorter sleep duration than their corresponding controls. Particularly, lean NAFLD patients consumed comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLDpatients, though they consumed lower levels of grain, potato, and fruit (lean NAFLD patients vs. obese NAFLDpatients: mean ± SD, g/day grain: 291.8 ± 83.8, 365.2 ± 89.0; potato: 63.5 ± 33.1, 80.4 ± 37.6; fruit: 324.3 ± 148.4, 414.0 ± 220.4; P < 0.0001). CONCLUSION:Non-alcoholic fatty liver diseasepatients had higher total caloric, calorigenic nutrients, grain, potato, fruit, iron, and overtime work but shorter sleep duration. Lean NAFLD patients had comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLDpatients. These features could be used to the nutritional education and therapeutic guidance for lean NAFLD patients in the future.
Authors: Mi Na Kim; Kyungdo Han; Juhwan Yoo; Yeonjung Ha; Young Eun Chon; Ju Ho Lee; Tracey G Simon; Andrew T Chan; Seong Gyu Hwang Journal: Sci Rep Date: 2021-04-28 Impact factor: 4.379