Carole de Vaugelade1, Charles Mesguich2, Karine Nubret3, Fabrice Camou4, Carine Greib5, Gael Dournes6, Frédéric Debordeaux2, Elif Hindie2,7, Laurent Barandon7,8, Ghoufrane Tlili2. 1. Nuclear Medicine Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. carole.dvdb@gmail.com. 2. Nuclear Medicine Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 3. Cardiology Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 4. Intensive Care Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 5. Internal Medicine Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 6. Radiology Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 7. Univ. Bordeaux, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France. 8. Thoracic Surgery Department, CHU de Bordeaux, Avenue de Magellan, 33604, Pessac, France.
Abstract
BACKGROUND: The usage of left-ventricular-assist device (LVAD) is increasing in patients presenting with advanced heart failure. However, device-related infections are a challenge to recognize and to treat, with an important morbidity and mortality rate. The role of nuclear medicine imaging remains not well established for LVAD infections. The present study compared the accuracy of positron emission tomography/computed tomography with 18F-fludeoxyglucose (18F-FDG PET/CT) and radiolabeled leucocyte scintigraphy for the diagnosis of infections in patients supported with a continuous-flow LVAD. METHODS: From a prospectively maintained database, we retrospectively analyzed the diagnostic performance of radiolabeled leucocyte scintigraphy and 18F-FDG PET/CT in 24 patients who had a LVAD with a suspected device-related infection. Both examinations were routinely performed in all patients. Infection was assessed by the International Society for Heart and Lung Transplantation criteria. RESULTS: Twenty-four patients were included: 15 had a specific VAD infection (5 cardiac-LVAD and 10 driveline), 6 had a VAD-related infection, while 3 patients had a non-VAD-related infection. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 95.2%, 66.7%, 95.2%, 66.7%, and 91.6%, respectively, for 18F-FDG-PET; and 71.4%, 100%, 100%, 33.3%, and 75%, respectively, for leucocyte scintigraphy. 18F-FDG PET/CT showed significantly higher sensitivity (P = 0.01) than leucocyte scintigraphy. CONCLUSION: 18F-FDG PET/CT and radiolabeled leucocyte scintigraphy single-photon emission computed tomography carry high performance in the diagnostic of LVAD infections. 18F-FDG PET/CT shows significantly higher sensitivity and could be proposed as first-line nuclear medicine procedure.
BACKGROUND: The usage of left-ventricular-assist device (LVAD) is increasing in patients presenting with advanced heart failure. However, device-related infections are a challenge to recognize and to treat, with an important morbidity and mortality rate. The role of nuclear medicine imaging remains not well established for LVAD infections. The present study compared the accuracy of positron emission tomography/computed tomography with 18F-fludeoxyglucose (18F-FDG PET/CT) and radiolabeled leucocyte scintigraphy for the diagnosis of infections in patients supported with a continuous-flow LVAD. METHODS: From a prospectively maintained database, we retrospectively analyzed the diagnostic performance of radiolabeled leucocyte scintigraphy and 18F-FDG PET/CT in 24 patients who had a LVAD with a suspected device-related infection. Both examinations were routinely performed in all patients. Infection was assessed by the International Society for Heart and Lung Transplantation criteria. RESULTS: Twenty-four patients were included: 15 had a specific VAD infection (5 cardiac-LVAD and 10 driveline), 6 had a VAD-related infection, while 3 patients had a non-VAD-related infection. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 95.2%, 66.7%, 95.2%, 66.7%, and 91.6%, respectively, for 18F-FDG-PET; and 71.4%, 100%, 100%, 33.3%, and 75%, respectively, for leucocyte scintigraphy. 18F-FDG PET/CT showed significantly higher sensitivity (P = 0.01) than leucocyte scintigraphy. CONCLUSION:18F-FDG PET/CT and radiolabeled leucocyte scintigraphy single-photon emission computed tomography carry high performance in the diagnostic of LVAD infections. 18F-FDG PET/CT shows significantly higher sensitivity and could be proposed as first-line nuclear medicine procedure.
Authors: Margaret M Hannan; Shahid Husain; Frauke Mattner; Lara Danziger-Isakov; Richard J Drew; G Ralph Corey; Stephan Schueler; William L Holman; Leo P Lawler; Steve M Gordon; Niall G Mahon; John M Herre; Kate Gould; Jose G Montoya; Robert F Padera; Robert L Kormos; John V Conte; Martha L Mooney Journal: J Heart Lung Transplant Date: 2011-04 Impact factor: 10.247
Authors: Daniel Juneau; Mohammad Golfam; Samir Hazra; Lionel S Zuckier; Shady Garas; Calum Redpath; Jordan Bernick; Eugene Leung; Sharon Chih; George Wells; Rob S B Beanlands; Benjamin J W Chow Journal: Circ Cardiovasc Imaging Date: 2017-04 Impact factor: 7.792
Authors: Angelo Maria Dell'Aquila; Stefano Mastrobuoni; Sebastian Alles; Christian Wenning; Welp Henryk; Stefan Rudolf Bertram Schneider; Heinz Deschka; Jürgen R Sindermann; Mirela Scherer Journal: Ann Thorac Surg Date: 2015-10-01 Impact factor: 4.330
Authors: Ana Jiménez-Ballvé; María Jesús Pérez-Castejón; Roberto C Delgado-Bolton; Cristina Sánchez-Enrique; Isidre Vilacosta; David Vivas; Carmen Olmos; Manuel E Fuentes Ferrer; José L Carreras-Delgado Journal: Eur J Nucl Med Mol Imaging Date: 2016-09-05 Impact factor: 9.236
Authors: Erik F J de Vries; Manel Roca; Francois Jamar; Ora Israel; Alberto Signore Journal: Eur J Nucl Med Mol Imaging Date: 2010-04 Impact factor: 9.236
Authors: Trine K Lauridsen; Kasper K Iversen; Nikolaj Ihlemann; Philip Hasbak; Annika Loft; Anne K Berthelsen; Anders Dahl; Danijela Dejanovic; Elisabeth Albrecht-Beste; Jann Mortensen; Andreas Kjær; Henning Bundgaard; Niels Eske Bruun Journal: Int J Cardiovasc Imaging Date: 2017-01-03 Impact factor: 2.357
Authors: Gilbert Habib; Patrizio Lancellotti; Manuel J Antunes; Maria Grazia Bongiorni; Jean-Paul Casalta; Francesco Del Zotti; Raluca Dulgheru; Gebrine El Khoury; Paola Anna Erba; Bernard Iung; Jose M Miro; Barbara J Mulder; Edyta Plonska-Gosciniak; Susanna Price; Jolien Roos-Hesselink; Ulrika Snygg-Martin; Franck Thuny; Pilar Tornos Mas; Isidre Vilacosta; Jose Luis Zamorano Journal: Eur Heart J Date: 2015-08-29 Impact factor: 29.983
Authors: Soile Pauliina Salomäki; Antti Saraste; Jukka Kemppainen; Jeroen J Bax; Juhani Knuuti; Pirjo Nuutila; Marko Seppänen; Anne Roivainen; Juhani Airaksinen; Laura Pirilä; Jarmo Oksi; Ulla Hohenthal Journal: J Nucl Cardiol Date: 2015-12-09 Impact factor: 5.952
Authors: Sakir Akin; Rahat Muslem; Alina A Constantinescu; Olivier C Manintveld; Ozcan Birim; Jasper J Brugts; Alexander P W M Maat; Alida C Fröberg; Ad J J C Bogers; Kadir Caliskan Journal: ASAIO J Date: 2018 Mar/Apr Impact factor: 2.872
Authors: Saul N Friedman; Maryam Mahmood; Jennifer R Geske; Muhammad Rizwan Sohail; Geoffrey B Johnson; John M Stulak; Ayse Tuba Kendi Journal: Am J Nucl Med Mol Imaging Date: 2020-12-15
Authors: Jan M Sommerlath Sohns; Hannah Kröhn; Alexandra Schöde; Thorsten Derlin; Axel Haverich; Jan D Schmitto; Frank M Bengel Journal: J Nucl Med Date: 2019-12-05 Impact factor: 11.082
Authors: Radoslav Zinoviev; Christopher K Lippincott; Sara C Keller; Nisha A Gilotra Journal: Open Forum Infect Dis Date: 2020-04-17 Impact factor: 3.835
Authors: D Ten Hove; G Treglia; R H J A Slart; K Damman; M Wouthuyzen-Bakker; D F Postma; O Gheysens; R J H Borra; G Mecozzi; P P van Geel; B Sinha; A W J M Glaudemans Journal: Eur J Nucl Med Mol Imaging Date: 2020-06-27 Impact factor: 9.236
Authors: Riemer H J A Slart; Andor W J M Glaudemans; Olivier Gheysens; Mark Lubberink; Tanja Kero; Marc R Dweck; Gilbert Habib; Oliver Gaemperli; Antti Saraste; Alessia Gimelli; Panagiotis Georgoulias; Hein J Verberne; Jan Bucerius; Christoph Rischpler; Fabien Hyafil; Paola A Erba Journal: Eur Heart J Cardiovasc Imaging Date: 2020-12-01 Impact factor: 6.875