| Literature DB >> 2994829 |
M M Haglund, W L Stahl, D D Kunkel, P A Schwartzkroin.
Abstract
Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.Entities:
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Year: 1985 PMID： 2994829 DOI： 10.1016/0006-8993(85)91180-1
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252