Literature DB >> 29945844

Illuminating GPCR Signaling by Cryo-EM.

Haaris Ahsan Safdari1, Shubhi Pandey2, Arun K Shukla3, Somnath Dutta4.   

Abstract

The wave of resolution revolution in cryo-EM has touched, and made a significant impact on, the structural biology of GPCRs. High-resolution structures of several GPCR-G-protein complexes are now determined by cryo-EM and they illuminate fine structural details of this central macromolecular complex involved in cellular signaling.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Keywords:  GPCR; arrestins; biased signaling; cryo-EM; negative-staining

Mesh：

Substances：

Year:  2018        PMID： 29945844     DOI： 10.1016/j.tcb.2018.06.002

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  19 in total

Review 1.  Extramembranous Regions in G Protein-Coupled Receptors: Cinderella in Receptor Biology?

Authors:  Sreetama Pal; Amitabha Chattopadhyay
Journal:  J Membr Biol       Date:  2019-08-30       Impact factor: 1.843

2.  The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.

Authors:  Martha E Sommer; Jana Selent; Jens Carlsson; Chris De Graaf; David E Gloriam; Gyorgy M Keseru; Mickey Kosloff; Stefan Mordalski; Aurelien Rizk; Mette M Rosenkilde; Eddy Sotelo; Johanna K S Tiemann; Andrew Tobin; Nina Vardjan; Maria Waldhoer; Peter Kolb
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-31

Review 3.  Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses.

Authors:  Ram Prasad Bhusal; Simon R Foster; Martin J Stone
Journal:  Protein Sci       Date:  2019-10-24       Impact factor: 6.725

Review 4.  AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors.

Authors:  Xin-Heng He; Chong-Zhao You; Hua-Liang Jiang; Yi Jiang; H Eric Xu; Xi Cheng
Journal:  Acta Pharmacol Sin       Date:  2022-07-01       Impact factor: 6.150

Review 5.  Molecular Basis of Opioid Action: From Structures to New Leads.

Authors:  Aashish Manglik
Journal:  Biol Psychiatry       Date:  2019-09-12       Impact factor: 13.382

Review 6.  Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.

Authors:  Eric A Wold; Jianping Chen; Kathryn A Cunningham; Jia Zhou
Journal:  J Med Chem       Date:  2018-08-28       Impact factor: 7.446

Review 7.  Therapeutic potential of ectopic olfactory and taste receptors.

Authors:  Sung-Joon Lee; Inge Depoortere; Hanns Hatt
Journal:  Nat Rev Drug Discov       Date:  2019-02       Impact factor: 84.694

8.  EMNUSS: a deep learning framework for secondary structure annotation in cryo-EM maps.

Authors:  Jiahua He; Sheng-You Huang
Journal:  Brief Bioinform       Date:  2021-11-05       Impact factor: 11.622

Review 9.  [Single-particle cryo-electron microscopy opens new avenues in structural biology of G protein-coupled receptor].

Authors:  Chuntao Li; Huibing Zhang; Yan Zhang
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2019-05-25

10.  Cholesterol in GPCR Structures: Prevalence and Relevance.

Authors:  Parijat Sarkar; Amitabha Chattopadhyay
Journal:  J Membr Biol       Date:  2021-08-07       Impact factor: 1.843
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