Literature DB >> 2994073

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.

J Vergara, R Y Tsien, M Delay.   

Abstract

The role of inositol 1,4,5-trisphosphate (InsP3) in excitation-contraction coupling in skeletal muscle was investigated by several methods. The following results were obtained. InsP3 is released by electrical stimulation of muscles. Exogenous InsP3 releases calcium from skinned muscle fibers at relatively high doses under normal conditions but does so at very low concentrations when blockers of the InsP3 5-phosphatase are present. Blockers of InsP3 release are effective blockers of calcium transients elicited by electrical stimulation of muscle fibers. It is proposed that InsP3 acts as a chemical second messenger between transverse (T)-tubular membrane depolarization and calcium release from the sarcoplasmic reticulum in skeletal muscle.

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Year:  1985        PMID： 2994073      PMCID： PMC391052          DOI： 10.1073/pnas.82.18.6352

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

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Journal:  Nature       Date:  1983 Sep 22-28       Impact factor: 49.962

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Journal:  Nature       Date:  1983 Nov 3-9       Impact factor: 49.962

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Journal:  Gen Physiol Biophys       Date:  1983-10       Impact factor: 1.512

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Journal:  J Gen Physiol       Date:  1982-04       Impact factor: 4.086
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  101 in total

1.  A novel role for membrane potential in the modulation of intracellular Ca2+ oscillations in rat megakaryocytes.

Authors:  M J Mason; J F Hussain; M P Mahaut-Smith
Journal:  J Physiol       Date:  2000-04-15       Impact factor: 5.182

2.  Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus.

Authors:  D F van Helden; M S Imtiaz; K Nurgaliyeva; P von der Weid; P J Dosen
Journal:  J Physiol       Date:  2000-04-01       Impact factor: 5.182

3.  Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyte.

Authors:  Juan Martinez-Pinna; Gwen Tolhurst; Iman S Gurung; Jamie I Vandenberg; Martyn P Mahaut-Smith
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4.  Quantitative analysis of depolarization-induced ATP release from mouse brain synaptosomes: external calcium dependent and independent processes.

Authors:  J L Fiedler; H B Pollard; E Rojas
Journal:  J Membr Biol       Date:  1992-04       Impact factor: 1.843

5.  A theoretical model of slow wave regulation using voltage-dependent synthesis of inositol 1,4,5-trisphosphate.

Authors:  Mohammad S Imtiaz; David W Smith; Dirk F van Helden
Journal:  Biophys J       Date:  2002-10       Impact factor: 4.033

6.  Depolarization-evoked Ca2+ release in a non-excitable cell, the rat megakaryocyte.

Authors:  M P Mahaut-Smith; J F Hussain; M J Mason
Journal:  J Physiol       Date:  1999-03-01       Impact factor: 5.182

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10.  Alteration of calcium sensitivity of skinned frog skeletal muscle fibres by inositol triphosphate and calmodulin antagonists.

Authors:  M Isac; I Morano; J C Rüegg
Journal:  Pflugers Arch       Date:  1988-08       Impact factor: 3.657
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