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Literature DB >> 29937401

HDAC6 at Crossroads of Infection and Innate Immunity.

Olga Moreno-Gonzalo¹, Federico Mayor², Francisco Sánchez-Madrid³.

Abstract

Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.

Entities: Disease Gene

Keywords: HDAC6; autophagy; bacterial and viral infection; deacetylase; inflammation; innate immunity

Mesh：

Substances：

Year: 2018 PMID： 29937401 DOI： 10.1016/j.it.2018.05.004

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

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Cited

6 in total

Review 1. Molecular Mechanisms of Vascular Damage During Lung Injury.

Authors: Ramon Bossardi Ramos; Alejandro Pablo Adam
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

2. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.

Authors: Olasunkanmi O Olaoye; Paris R Watson; Nabanita Nawar; Mulu Geletu; Abootaleb Sedighi; Shazreh Bukhari; Yasir S Raouf; Pimyupa Manaswiyoungkul; Fettah Erdogan; Ayah Abdeldayem; Aaron D Cabral; Muhammad Murtaza Hassan; Krimo Toutah; Andrew E Shouksmith; Justyna M Gawel; Johan Israelian; Tudor B Radu; Niyati Kachhiyapatel; Elvin D de Araujo; David W Christianson; Patrick T Gunning
Journal: J Med Chem Date: 2021-02-12 Impact factor: 7.446

HDAC6 at Crossroads of Infection and Innate Immunity.

Review 1. Molecular Mechanisms of Vascular Damage During Lung Injury.

2. Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.

Review 3. G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub.

Review 4. HDAC6-an Emerging Target Against Chronic Myeloid Leukemia?

5. Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019.

6. Alleviation of depression-like behavior in a cystic fibrosis mouse model by Hdac6 depletion.