Hui-Yu Chang1, Yu-Kai Tseng2, Yu-Chia Chen3, Chih-Wen Shu1, Miaw-I Lin4, Huei-Han Liou1, Ting-Ying Fu5, Yun-Chung Lin6, Luo-Ping Ger7, Ming-Hsin Yeh8, Pei-Feng Liu9. 1. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan. 2. Department of Orthopedics, Show Chwan Memorial Hospital, Changhua 50008, Taiwan; Department of Orthopedics, National Cheng Kung University Hospital, Tainan 70401, Taiwan. 3. Department of General Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan. 4. Department of Nursing, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan; Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan. 5. Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan. 6. Department of Pathology, China Medical University Hospital, Taichung 40447, Taiwan. 7. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. 8. Department of Surgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. Electronic address: breast5321@gmail.com. 9. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan; Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan. Electronic address: pfliu@vghks.gov.tw.
Abstract
BACKGROUND: High Snail expression is known as a poor prognostic factor in breast cancer. However, its prognostic impact for breast cancer with different molecular subtypes is still controversial. METHODS: Snail expression was examined by immunohistochemistry in tissue microarray slides of 85 corresponding tumor-adjacent normal (CTAN) and 247 breast invasive ductal carcinoma (IDC) tissues. Multivariable Cox regression analysis was used to assess the impact of Snail expression on survival rate by different molecular subtypes of breast IDC patients. RESULTS: The level of Snail expression in IDC tumor tissues was significantly higher than that in CTAN tissues. Moreover, high Snail expression had direct impacts on poor disease specific survival (DSS) and disease-free survival (DFS) in breast IDC patients with human epidermal growth factor receptor 2 (HER2)-positive and human epidermal growth factor receptor (EGFR)-positive statuses as well as the HER2 intrinsic subtype. Additionally, breast IDC patients with a combination of three prognostic factors, including high Snail expression and HER2-positive and EGFR-positive statuses, had much poor DSS and DFS with a statistically significant linear trend. CONCLUSION: High Snail expression could predict a poor prognosis for breast IDC patients with HER2/EGFR-positive subtypes.
BACKGROUND: High Snail expression is known as a poor prognostic factor in breast cancer. However, its prognostic impact for breast cancer with different molecular subtypes is still controversial. METHODS:Snail expression was examined by immunohistochemistry in tissue microarray slides of 85 corresponding tumor-adjacent normal (CTAN) and 247 breast invasive ductal carcinoma (IDC) tissues. Multivariable Cox regression analysis was used to assess the impact of Snail expression on survival rate by different molecular subtypes of breast IDCpatients. RESULTS: The level of Snail expression in IDC tumor tissues was significantly higher than that in CTAN tissues. Moreover, high Snail expression had direct impacts on poor disease specific survival (DSS) and disease-free survival (DFS) in breast IDCpatients with humanepidermal growth factor receptor 2 (HER2)-positive and humanepidermal growth factor receptor (EGFR)-positive statuses as well as the HER2 intrinsic subtype. Additionally, breast IDCpatients with a combination of three prognostic factors, including high Snail expression and HER2-positive and EGFR-positive statuses, had much poor DSS and DFS with a statistically significant linear trend. CONCLUSION: High Snail expression could predict a poor prognosis for breast IDCpatients with HER2/EGFR-positive subtypes.
Authors: Rogério Agenor de Araújo; Felipe Andrés Cordero da Luz; Eduarda da Costa Marinho; Camila Piqui Nascimento; Lara de Andrade Marques; Patrícia Ferreira Ribeiro Delfino; Rafael Mathias Antonioli; Breno Jeha Araújo; Ana Cristina Araújo Lemos da Silva; Maria Luiza Gonçalves Dos Reis Monteiro; Morun Bernardino Neto; Marcelo José Barbosa Silva Journal: Ecancermedicalscience Date: 2022-07-20