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Literature DB >> 29936233

The neurobiological effects of repetitive head impacts in collision sports.

Liane E Hunter¹, Craig A Branch², Michael L Lipton³.

Abstract

It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.

Entities: Chemical Disease Gene Mutation Species

Keywords: Collision sports; Mild traumatic brain injury; Repetitive head injuries

Mesh：

Substances：
tau Proteins

Year: 2018 PMID： 29936233 PMCID： PMC6453577 DOI： 10.1016/j.nbd.2018.06.016

Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996

69 in total

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Authors: M R Graham; T Myers; P Evans; B Davies; S M Cooper; K Bhattacharya; F M Grace; J S Baker
Journal: Int J Immunopathol Pharmacol Date: 2011 Jan-Mar Impact factor: 3.219

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Journal: J Neurochem Date: 2014-03-19 Impact factor: 5.372

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Journal: J Clin Neurosci Date: 2016-10-18 Impact factor: 1.961

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Journal: J Neurotrauma Date: 2012-08-17 Impact factor: 5.269

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Authors: Barbara Tavazzi; Roberto Vagnozzi; Stefano Signoretti; Angela M Amorini; Antonio Belli; Marco Cimatti; Roberto Delfini; Valentina Di Pietro; Antonino Finocchiaro; Giuseppe Lazzarino
Journal: Neurosurgery Date: 2007-08 Impact factor: 4.654

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Authors: Weidong Zhou; Di Xu; Xiaoxia Peng; Qiuhong Zhang; Jianping Jia; Keith A Crutcher
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Journal: Front Neurol Date: 2016-10-31 Impact factor: 4.003

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Authors: Alex P Di Battista; Shawn G Rhind; Doug Richards; Nathan Churchill; Andrew J Baker; Michael G Hutchison
Journal: PLoS One Date: 2016-07-26 Impact factor: 3.240

11 in total

1. PREFACE: Antiepileptogenesis following traumatic brain injury.

Authors: Aristea S Galanopoulou; Jerome Engel; Solomon L Moshé
Journal: Neurobiol Dis Date: 2018-10-09 Impact factor: 5.996

2. Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.

Authors: Enora Le Flao; Gunter P Siegmund; Robert Borotkanics
Journal: Sports Med Date: 2021-10-22 Impact factor: 11.136

Review 3. A Systematic Review of Head Impacts and Acceleration Associated with Soccer.

Authors: Ioannis Basinas; Damien M McElvenny; Neil Pearce; Valentina Gallo; John W Cherrie
Journal: Int J Environ Res Public Health Date: 2022-05-01 Impact factor: 4.614

4. Concussion History and Neuromechanical Responsiveness Asymmetry.

Authors: Gary B Wilkerson; Dustin C Nabhan; Ryan T Crane
Journal: J Athl Train Date: 2020-06-23 Impact factor: 2.860

Review 5. Purposeful Heading in Youth Soccer: A Review.

Authors: Victoria E Wahlquist; Thomas W Kaminski
Journal: Sports Med Date: 2021-01 Impact factor: 11.136

6. Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders.

Authors: Samuel F Yanuck
Journal: Front Psychiatry Date: 2019-10-03 Impact factor: 4.157

10. Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans.

Authors: Sarah J Benbow; Timothy J Strovas; Martin Darvas; Aleen Saxton; Brian C Kraemer
Journal: Hum Mol Genet Date: 2020-02-01 Impact factor: 6.150