| Literature DB >> 29936025 |
Katsutoshi Sugimoto1, Fuminori Moriyasu2, Hisashi Oshiro3, Hirohito Takeuchi4, Yu Yoshimasu4, Yoshitaka Kasai4, Yoshihiro Furuichi4, Takao Itoi4.
Abstract
To investigate the usefulness of shear-wave speed and dispersion slope measurements obtained, using an ultrasound elastography system in rat livers with various degrees of necroinflammation and fibrosis. A total of 25 male Sprague Dawley rats were randomly divided into 5 groups of 5 rats each: G0 (control), G1 (CCl4 injected twice a week for 1 wk), G2 (CCl4 injected four times a wk for 1 wk), G3 (CCl4 injected twice a wk for 6 wk) and G4 (CCl4 injected twice a wk for 10 wk). The shear-wave speed (m/s) and the dispersion slope ([m/s]/kHz) were measured. Histologic features (inflammation, necrosis and fibrosis) were used as reference standards. In multivariable analysis with histologic features as independent variables, the fibrosis grade was significantly related to shear-wave speed (p < 0.05) and the necrosis grade was significantly related to dispersion slope (p < 0.05). Dispersion slope is more useful than shear-wave speed for predicting the degree of necroinflammation.Entities:
Keywords: Dispersion; Liver; Shear-wave elastography; Shear-wave speed; Ultrasound; Viscoelasticity; Viscosity
Mesh：
Year: 2018 PMID： 29936025 DOI： 10.1016/j.ultrasmedbio.2018.05.008
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998