Yu-Li Lin1, Hung-Hsiang Liou2, Yu-Hsien Lai1, Chih-Hsien Wang1, Chiu-Huang Kuo1, Shu-Yuan Chen3, Bang-Gee Hsu4. 1. Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 2. Division of Nephrology, Department of Internal Medicine, Hsin-Jen Hospital, New Taipei City, Taiwan. 3. Department of Public Health, Tzu Chi University, Hualien, Taiwan. Electronic address: sychen02@mail.tcu.edu.tw. 4. Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address: gee.lily@msa.hinet.net.
Abstract
BACKGROUND: Fatty acid binding protein 4 (FABP4) is found to play a role in skeletal muscle homeostasis. Since the dysregulation of FABP4 and sarcopenia are both highly prevalent in patients on chronic hemodialysis (HD), the correlation between them remains unknown. We aimed to examine this relationship in a cross-sectional study. METHODS: A total of 120 chronic HD patients were recruited, and whose skeletal muscle mass, handgrip strength, and gait speed were assessed and blood samples were obtained. We grouped these participants into sarcopenia (n = 20) and non-sarcopenia groups according to European Working Group on Sarcopenia in Older People criteria. RESULTS: The sarcopenia group exhibited lower weight (P < 0.001), height (P = 0.019), waist circumference (P < 0.001), body mass index (P < 0.001), body fat mass (P = 0.004), and lower serum triglycerides (P = 0.009), creatinine (P < 0.001), phosphorus (P = 0.013), intact parathyroid hormone (P = 0.012), and FABP4 concentrations (P = 0.005), and higher malnutrition-inflammation scores (MIS) (P = 0.031), urea reduction rates (P < 0.001), and fractional clearance index for urea (Kt/V) values (P < 0.001). Serum FABP4 concentrations (odds ratio (OR): 0.98, 95% confidence interval (CI): 0.96-0.99, P = 0.043), body fat mass (OR: 0.86, 95% CI: 0.77-0.97, P = 0.013), MIS (OR: 6.90, 95% CI: 1.31-36.36, P = 0.023), and Kt/V (each increase of 0.1, OR: 2.15, 95% CI: 1.29-3.57, P = 0.003) were independent predictors of sarcopenia in chronic HD patients. CONCLUSIONS: We delineated the association between serum FABP4 concentrations and sarcopenia in chronic HD patients.
BACKGROUND:Fatty acid binding protein 4 (FABP4) is found to play a role in skeletal muscle homeostasis. Since the dysregulation of FABP4 and sarcopenia are both highly prevalent in patients on chronic hemodialysis (HD), the correlation between them remains unknown. We aimed to examine this relationship in a cross-sectional study. METHODS: A total of 120 chronic HDpatients were recruited, and whose skeletal muscle mass, handgrip strength, and gait speed were assessed and blood samples were obtained. We grouped these participants into sarcopenia (n = 20) and non-sarcopenia groups according to European Working Group on Sarcopenia in Older People criteria. RESULTS: The sarcopenia group exhibited lower weight (P < 0.001), height (P = 0.019), waist circumference (P < 0.001), body mass index (P < 0.001), body fat mass (P = 0.004), and lower serum triglycerides (P = 0.009), creatinine (P < 0.001), phosphorus (P = 0.013), intact parathyroid hormone (P = 0.012), and FABP4 concentrations (P = 0.005), and higher malnutrition-inflammation scores (MIS) (P = 0.031), urea reduction rates (P < 0.001), and fractional clearance index for urea (Kt/V) values (P < 0.001). Serum FABP4 concentrations (odds ratio (OR): 0.98, 95% confidence interval (CI): 0.96-0.99, P = 0.043), body fat mass (OR: 0.86, 95% CI: 0.77-0.97, P = 0.013), MIS (OR: 6.90, 95% CI: 1.31-36.36, P = 0.023), and Kt/V (each increase of 0.1, OR: 2.15, 95% CI: 1.29-3.57, P = 0.003) were independent predictors of sarcopenia in chronic HDpatients. CONCLUSIONS: We delineated the association between serum FABP4 concentrations and sarcopenia in chronic HDpatients.