Lana Fani1, Frank J Wolters2, M Kamran Ikram2, Marco J Bruno3, Albert Hofman4, Peter J Koudstaal5, Sarwa Darwish Murad6, M Arfan Ikram7. 1. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. 2. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. 3. Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. 4. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. 6. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. 7. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. Electronic address: m.a.ikram@erasmusmc.nl.
Abstract
INTRODUCTION: Helicobacter pylori infection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population-based cohort. METHODS: Between 1997 and 2002, we measured H. pylori serum IgG titers in 4215 nondemented participants of the Rotterdam Study with a mean age of 69 years. We determined the association between H. pylori at baseline and dementia incidence until 2015, per natural log (U/mL) increase in titer, and for seropositive/seronegative, using Cox models adjusting for cohort, sex, age, education, and cardiovascular risk factors. RESULTS: During a median follow-up of 13.3 years, 529 participants developed dementia, of which 463 had Alzheimer's disease. H. pylori was not associated with risk of dementia (hazard ratio [95% confidence interval] for antibody titer: 1.04 [0.90-1.21]; for seropositivity 1.03 [0.86-1.22]), or Alzheimer's disease. DISCUSSION: In this community-dwelling population, H. pylori was not associated with dementia risk.
INTRODUCTION:Helicobacter pyloriinfection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population-based cohort. METHODS: Between 1997 and 2002, we measured H. pylori serum IgG titers in 4215 nondemented participants of the Rotterdam Study with a mean age of 69 years. We determined the association between H. pylori at baseline and dementia incidence until 2015, per natural log (U/mL) increase in titer, and for seropositive/seronegative, using Cox models adjusting for cohort, sex, age, education, and cardiovascular risk factors. RESULTS: During a median follow-up of 13.3 years, 529 participants developed dementia, of which 463 had Alzheimer's disease. H. pylori was not associated with risk of dementia (hazard ratio [95% confidence interval] for antibody titer: 1.04 [0.90-1.21]; for seropositivity 1.03 [0.86-1.22]), or Alzheimer's disease. DISCUSSION: In this community-dwelling population, H. pylori was not associated with dementia risk.
Authors: Pyry N Sipilä; Joni V Lindbohm; Archana Singh-Manoux; Martin J Shipley; Tuomo Kiiskinen; Aki S Havulinna; Jussi Vahtera; Solja T Nyberg; Jaana Pentti; Mika Kivimäki Journal: Alzheimers Dement Date: 2020-09-04 Impact factor: 16.655