Literature DB >> 29934602

Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.

Satoshi Ōmura1, Yukihiro Asami2, Andy Crump2.   

Abstract

Staurosporine, together with such examples as penicillin, aspirin, ivermectin and sildenafil, exemplifies the role that serendipity has in drug discovery and why 'finding things without actually searching for them' retains a prominent role in drug discovery. Hitherto not clinically useful, due to its potency and promiscuity, new delivery technology is opening up new horizons for what was previously just the parent compound of innovative, highly-successful anti-cancer agents.

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Year:  2018        PMID： 29934602     DOI： 10.1038/s41429-018-0029-z

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

1.  Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure.

Authors:  Takaharu Sakuragi; Hidetaka Kosako; Shigekazu Nagata
Journal:  Proc Natl Acad Sci U S A       Date:  2019-02-04       Impact factor: 11.205

2.  Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine.

Authors:  Audrey E Yñigez-Gutierrez; Brian O Bachmann
Journal:  J Med Chem       Date:  2019-04-26       Impact factor: 7.446

3.  Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.

Authors:  Marcus J C Long; Ann P Lawson; Rick Baggio; Yu Qian; Lior Rozhansky; Domenico Fasci; Farid El Oualid; Eranthie Weerapana; Lizbeth Hedstrom
Journal:  Bioorg Med Chem Lett       Date:  2018-11-28       Impact factor: 2.823

4.  Activation of GSK3 Prevents Termination of TNF-Induced Signaling.

Authors:  Bastian Welz; Rolf Bikker; Korbinian Brand; René Huber; Leonie Hoffmeister; Mareike Diekmann; Martin Christmann
Journal:  J Inflamm Res       Date:  2021-05-06

5.  Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties.

Authors:  Marija Mojicevic; Paul M D'Agostino; Aleksandar Pavic; Sandra Vojnovic; Ramsankar Senthamaraikannan; Branka Vasiljevic; Tobias A M Gulder; Jasmina Nikodinovic-Runic
Journal:  Microbiologyopen       Date:  2020-01-28       Impact factor: 3.139

6.  A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite.

Authors:  Fleurdeliz Maglangit; Qing Fang; Kwaku Kyeremeh; Jeremy M Sternberg; Rainer Ebel; Hai Deng
Journal:  Molecules       Date:  2020-01-08       Impact factor: 4.411

7.  Screening for Sulfur Compounds by Molybdenum-Catalyzed Oxidation Combined with Liquid Chromatography-Mass Spectrometry.

Authors:  Hirotaka Matsuo; Yu Hanamure; Rei Miyano; Yōko Takahashi; Satoshi Ōmura; Takuji Nakashima
Journal:  Molecules       Date:  2020-01-07       Impact factor: 4.411

8.  Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery.

Authors:  Crhisllane Rafaele Dos Santos Vasconcelos; Antonio Mauro Rezende
Journal:  Front Chem       Date:  2021-04-27       Impact factor: 5.221

9.  Cytotoxic impact of a perillyl alcohol-temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro.

Authors:  Catalina Silva-Hirschberg; Hannah Hartman; Samantha Stack; Steve Swenson; Radu O Minea; Michael A Davitz; Thomas C Chen; Axel H Schönthal
Journal:  Ther Adv Med Oncol       Date:  2019-12-06       Impact factor: 8.168

Review 10.  Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors.

Authors:  Joan Serrano-Marín; Irene Reyes-Resina; Eva Martínez-Pinilla; Gemma Navarro; Rafael Franco
Journal:  Molecules       Date:  2020-10-30       Impact factor: 4.411
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