BACKGROUND: Fragmented QRS reflects disturbances in the myocardium predisposing the heart to ventricular tachyarrhythmias. Recent studies suggest that fragmented QRS (fQRS) is associated with mortality in ST-elevation myocardial infarction (STEMI) patients who underwent percutaneous coronary intervention (PCI). However, a systematic review and meta-analysis of the literature has not been done. We assessed the association between fQRS and overall mortality in STEMI patients who subsequently underwent PCI by a systematic review and meta-analysis. METHODS: We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Studies included in our analysis were published cohort (prospective or retrospective) and case-control studies that compared overall mortality among STEMI patient with and without fQRS who underwent PCI. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian, and Laird to calculate risk ratios and 95% confidence intervals. RESULTS: Six studies from 2014 to 2017 were included in this meta-analysis involving 2,516 subjects with STEMI who underwent PCI (888 fQRS and 1,628 non-fQRS). Fragmented QRS was associated with overall mortality in STEMI patients who underwent PCI (pooled risk ratio = 3.87; 95% CI 1.96-7.66, I2 = 43%). CONCLUSION: Fragmented QRS was associated with increased overall mortality up to threefold. Our study suggests that fQRS could be an important tool for risk assessment in STEMI patients who underwent PCI.
BACKGROUND: Fragmented QRS reflects disturbances in the myocardium predisposing the heart to ventricular tachyarrhythmias. Recent studies suggest that fragmented QRS (fQRS) is associated with mortality in ST-elevation myocardial infarction (STEMI) patients who underwent percutaneous coronary intervention (PCI). However, a systematic review and meta-analysis of the literature has not been done. We assessed the association between fQRS and overall mortality in STEMI patients who subsequently underwent PCI by a systematic review and meta-analysis. METHODS: We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Studies included in our analysis were published cohort (prospective or retrospective) and case-control studies that compared overall mortality among STEMI patient with and without fQRS who underwent PCI. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian, and Laird to calculate risk ratios and 95% confidence intervals. RESULTS: Six studies from 2014 to 2017 were included in this meta-analysis involving 2,516 subjects with STEMI who underwent PCI (888 fQRS and 1,628 non-fQRS). Fragmented QRS was associated with overall mortality in STEMI patients who underwent PCI (pooled risk ratio = 3.87; 95% CI 1.96-7.66, I2 = 43%). CONCLUSION: Fragmented QRS was associated with increased overall mortality up to threefold. Our study suggests that fQRS could be an important tool for risk assessment in STEMI patients who underwent PCI.
Authors: Steen D Kristensen; Kristina G Laut; Jean Fajadet; Zuzana Kaifoszova; Petr Kala; Carlo Di Mario; William Wijns; Peter Clemmensen; Vaja Agladze; Loizos Antoniades; Khalid F Alhabib; Menko-Jan De Boer; Marc J Claeys; Dan Deleanu; Dariusz Dudek; Andrejs Erglis; Martine Gilard; Omer Goktekin; Giulio Guagliumi; Thorarinn Gudnason; Kim Wadt Hansen; Kurt Huber; Stefan James; Tomáš Janota; Siobhan Jennings; Olli Kajander; John Kanakakis; Kiril K Karamfiloff; Sasko Kedev; Ran Kornowski; Peter F Ludman; Béla Merkely; Davor Milicic; Ruslan Najafov; Francesca A Nicolini; Marko Noč; Miodrag Ostojic; Hélder Pereira; Dragana Radovanovic; Manel Sabaté; Mohamed Sobhy; Maxim Sokolov; Martin Studencan; Ibrahim Terzic; Steffen Wahler; Petr Widimsky Journal: Eur Heart J Date: 2014-01-12 Impact factor: 29.983
Authors: Barış Güngör; Kazım Serhan Özcan; Mehmet Baran Karataş; İrfan Şahin; Recep Öztürk; Osman Bolca Journal: Ann Noninvasive Electrocardiol Date: 2016-03-28 Impact factor: 1.468
Authors: Mithilesh K Das; Hussam Suradi; Waddah Maskoun; Mark A Michael; Changyu Shen; Jonathan Peng; Gopi Dandamudi; Jo Mahenthiran Journal: Circ Arrhythm Electrophysiol Date: 2008-07-14
Authors: N J Aquino; O A Centurión; J M Torales; L M Miño; K E Scavenius; J F Alderete; J C Candia; L B García; C Cáceres; J E Martínez; O A Lovera Journal: Curr Health Sci J Date: 2019-12-30