S Chiappetta1, R Weiner2. 1. Klinik für Adipositas- und Metabolische Chirurgie, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach am Main, Deutschland. sonja.chiappetta@sana.de. 2. Klinik für Adipositas- und Metabolische Chirurgie, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach am Main, Deutschland.
Abstract
BACKGROUND: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE). OBJECTIVE: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. MATERIAL AND METHODS: A systematic literature search was performed in MEDLINE via PubMed and in Clinicaltrials.gov. from inception to 13 March 2018. A total of 35 studies met the inclusion criteria: 19 retrospective studies, 8 retrospective comparative trials, 2 systematic reviews, 3 systematic reviews and meta-analyses and 3 randomized clinical trials. A total of eight randomized clinical trials regarding MGB/OAGB are currently registered at Clinicaltrials.gov. RESULTS: In this study 35 eligible studies were included reporting data on >15,000 patients. The 30-day mortality rate ranged from 0-0.9% and severe complications needing intervention ranged from 0.8-7%, whereas perioperative morbidity ranged from 3.2-10.8%. The use of MGB/OAGB induced substantial weight loss with a total weight loss of 31-38% after 1 year and 23-32% after 5 years. Moreover, it showed a resolution or improvement in all major obesity-related diseases. Studies evaluating endpoints, such as end organ damage in diabetes, reduction of cardiovascular events and extending survival are missing and are available only for the Roux-en Y gastric bypass. CONCLUSION: This systematic review confirms the advantages of MGB/OAGB regarding weight loss and the antidiabetic effect in the short-term in comparison to Roux-en Y gastric bypass and sleeve gastrectomy. The role of bile reflux as a possible risk factor for neoplastic lesions in the long-term remains a point of discussion. The results of the registered randomized controlled trials will provide a better evidence in the future.
BACKGROUND: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE). OBJECTIVE: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. MATERIAL AND METHODS: A systematic literature search was performed in MEDLINE via PubMed and in Clinicaltrials.gov. from inception to 13 March 2018. A total of 35 studies met the inclusion criteria: 19 retrospective studies, 8 retrospective comparative trials, 2 systematic reviews, 3 systematic reviews and meta-analyses and 3 randomized clinical trials. A total of eight randomized clinical trials regarding MGB/OAGB are currently registered at Clinicaltrials.gov. RESULTS: In this study 35 eligible studies were included reporting data on >15,000 patients. The 30-day mortality rate ranged from 0-0.9% and severe complications needing intervention ranged from 0.8-7%, whereas perioperative morbidity ranged from 3.2-10.8%. The use of MGB/OAGB induced substantial weight loss with a total weight loss of 31-38% after 1 year and 23-32% after 5 years. Moreover, it showed a resolution or improvement in all major obesity-related diseases. Studies evaluating endpoints, such as end organ damage in diabetes, reduction of cardiovascular events and extending survival are missing and are available only for the Roux-en Y gastric bypass. CONCLUSION: This systematic review confirms the advantages of MGB/OAGB regarding weight loss and the antidiabetic effect in the short-term in comparison to Roux-en Y gastric bypass and sleeve gastrectomy. The role of bile reflux as a possible risk factor for neoplastic lesions in the long-term remains a point of discussion. The results of the registered randomized controlled trials will provide a better evidence in the future.
Authors: Yingjun Quan; Ao Huang; Min Ye; Ming Xu; Biao Zhuang; Peng Zhang; Bo Yu; Zhijun Min Journal: Gastroenterol Res Pract Date: 2015-06-17 Impact factor: 2.260
Authors: Nienke Slagter; Jonne Hopman; Anna G Altenburg; Loek J M de Heide; Ewoud H Jutte; Mirjam A Kaijser; Stefan L Damen; André P van Beek; Marloes Emous Journal: Obes Surg Date: 2021-01-26 Impact factor: 4.129