Takeshi Takahashi1, Masahiro Harada1, Takaaki Kikuno2, Makoto Ujihara3, Daikai Sadamitsu4, Yasuhiro Manabe5, Masahiro Yasaka6, Hayato Takayama7, Shozo Kobori8, Eiichi Araki9. 1. Emergency and Critical Care Center of Kumamoto Medical Center National Hospital Organization Kumamoto Japan. 2. Emergency and Critical Care Center of Tokyo Medical Center National Hospital Organization Tokyo Japan. 3. Metabolic Medicine of Yokohama Medical Center National Hospital Organization Kanagawa Japan. 4. Emergency and Critical Care Center of Osaka Medical Center National Hospital Organization Osaka Japan. 5. Neurology of Okayama Medical Center National Hospital Organization Okayama Japan. 6. Neurology of Kyusyu Medical Center National Hospital Organization Fukuoka Japan. 7. Emergency and Critical Care Center of Nagasaki Medical Center National Hospital Organization Nagasaki Japan. 8. Metabolic Medicine of Miyazaki Hospital National Hospital Organization Miyazaki Japan. 9. Department of Metabolic Medicine, Faculty of Life Sciences Kumamoto University Kumamoto Japan.
Abstract
AIMS: The fact that Metabolic Syndrome (MetS) increases the risk of atherosclerosis has been epidemiologically studied and proven; however, a prospective study on the prevalence of MetS in stroke patients has never been conducted because of the difficulty in diagnosis under critical illness in the acute phase. Therefore, we conducted a prospective multicenter study to investigate the prevalence of MetS in stroke patients with modified diagnostic criteria for MetS. METHODS: Stroke patients admitted in the seven participating Emergency and Critical Care Centers within the two years from April 2007 were registered in this study as a prospective multicenter study. Inclusion criteria were 50 to 89 year-old stroke patients who presented within three days from the onset of symptoms. A total of 992 subjects were classified according to the stroke type and the prevalence of MetS and the associated risk factors were investigated. The participants in a medical checkup without any history of a stroke were enrolled as the control group, and compared between the two groups. RESULTS: The prevalence of MetS as well as hyperglycemia and dyslipidemia in the infarction group was significantly higher than that in the non-stroke group. While the hemorrhage group showed no significant difference in the prevalence of MetS, only hypertension was significantly high. According to a subtype analysis, there is a significant correlation between waist circumference increment of the stroke patients and the prevalence of the risk factors of hypertension, hyperglycemia and dyslipidemia. CONCLUSIONS: Different risk factors are significantly related to the type of stroke.
AIMS: The fact that Metabolic Syndrome (MetS) increases the risk of atherosclerosis has been epidemiologically studied and proven; however, a prospective study on the prevalence of MetS in stroke patients has never been conducted because of the difficulty in diagnosis under critical illness in the acute phase. Therefore, we conducted a prospective multicenter study to investigate the prevalence of MetS in stroke patients with modified diagnostic criteria for MetS. METHODS: Stroke patients admitted in the seven participating Emergency and Critical Care Centers within the two years from April 2007 were registered in this study as a prospective multicenter study. Inclusion criteria were 50 to 89 year-old stroke patients who presented within three days from the onset of symptoms. A total of 992 subjects were classified according to the stroke type and the prevalence of MetS and the associated risk factors were investigated. The participants in a medical checkup without any history of a stroke were enrolled as the control group, and compared between the two groups. RESULTS: The prevalence of MetS as well as hyperglycemia and dyslipidemia in the infarction group was significantly higher than that in the non-stroke group. While the hemorrhage group showed no significant difference in the prevalence of MetS, only hypertension was significantly high. According to a subtype analysis, there is a significant correlation between waist circumference increment of the stroke patients and the prevalence of the risk factors of hypertension, hyperglycemia and dyslipidemia. CONCLUSIONS: Different risk factors are significantly related to the type of stroke.
Authors: Fred Rincon; Ralph L Sacco; Grace Kranwinkel; Qiu Xu; Myungee C Paik; Bernadette Boden-Albala; Mitchell S V Elkind Journal: Cerebrovasc Dis Date: 2009-05-20 Impact factor: 2.762