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Literature DB >> 29929590

Pathophysiology of Itch.

Abstract

Chronic itch is a clinically challenging yet scientifically remarkable and complex process. Increasing understanding of the pathophysiology of chronic itch is leading to targeted therapeutic approaches that are now dramatically improving quality of life. This improvement will accelerate as the tools of basic and clinical research continue to be applied to this previously intractable problem.

Entities: Chemical Disease Gene Species

Keywords: Atopic dermatitis; Central sensitization; Chronic itch; Epigenetics; Pruritus

Mesh：

Year: 2018 PMID： 29929590 PMCID： PMC6022764 DOI： 10.1016/j.det.2018.02.001

Source DB: PubMed Journal: Dermatol Clin ISSN： 0733-8635 Impact factor: 3.478

10 in total

Review 1. Itch and pain differences and commonalities.

Authors: Martin Schmelz
Journal: Handb Exp Pharmacol Date: 2015

Review 2. Sensory neurons and circuits mediating itch.

Authors: Robert H LaMotte; Xinzhong Dong; Matthias Ringkamp
Journal: Nat Rev Neurosci Date: 2014-01 Impact factor: 34.870

3. A central neural circuit for itch sensation.

Authors: Di Mu; Juan Deng; Ke-Fei Liu; Zhen-Yu Wu; Yu-Feng Shi; Wei-Min Guo; Qun-Quan Mao; Xing-Jun Liu; Hui Li; Yan-Gang Sun
Journal: Science Date: 2017-08-18 Impact factor: 47.728

4. Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis.

Authors: Thomas Ruzicka; Jon M Hanifin; Masutaka Furue; Grazyna Pulka; Izabela Mlynarczyk; Andreas Wollenberg; Ryszard Galus; Takafumi Etoh; Ryosuke Mihara; Hiroki Yoshida; Jonathan Stewart; Kenji Kabashima
Journal: N Engl J Med Date: 2017-03-02 Impact factor: 91.245

Review 5. Molecular mechanisms of pruritus.

Authors: J Meng; M Steinhoff
Journal: Curr Res Transl Med Date: 2016-11-04 Impact factor: 4.513

6. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis.

Authors: Eric L Simpson; Thomas Bieber; Emma Guttman-Yassky; Lisa A Beck; Andrew Blauvelt; Michael J Cork; Jonathan I Silverberg; Mette Deleuran; Yoko Kataoka; Jean-Philippe Lacour; Külli Kingo; Margitta Worm; Yves Poulin; Andreas Wollenberg; Yuhwen Soo; Neil M H Graham; Gianluca Pirozzi; Bolanle Akinlade; Heribert Staudinger; Vera Mastey; Laurent Eckert; Abhijit Gadkari; Neil Stahl; George D Yancopoulos; Marius Ardeleanu
Journal: N Engl J Med Date: 2016-09-30 Impact factor: 91.245

7. Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.

Authors: Parul Sikand; Steven G Shimada; Barry G Green; Robert H LaMotte
Journal: Pain Date: 2009-05-06 Impact factor: 6.961

Review 8. Pruritus in patients treated with targeted cancer therapies: systematic review and meta-analysis.

Authors: Courtney J Ensslin; Alyx C Rosen; Shenhong Wu; Mario E Lacouture
Journal: J Am Acad Dermatol Date: 2013-08-24 Impact factor: 11.527

9. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

Authors: Landon K Oetjen; Madison R Mack; Jing Feng; Timothy M Whelan; Haixia Niu; Changxiong J Guo; Sisi Chen; Anna M Trier; Amy Z Xu; Shivani V Tripathi; Jialie Luo; Xiaofei Gao; Lihua Yang; Samantha L Hamilton; Peter L Wang; Jonathan R Brestoff; M Laurin Council; Richard Brasington; András Schaffer; Frank Brombacher; Chyi-Song Hsieh; Robert W Gereau; Mark J Miller; Zhou-Feng Chen; Hongzhen Hu; Steve Davidson; Qin Liu; Brian S Kim
Journal: Cell Date: 2017-09-07 Impact factor: 66.850

Review 10. The cell biology of acute itch.

Authors: Dustin Green; Xinzhong Dong
Journal: J Cell Biol Date: 2016-04-25 Impact factor: 10.539

10 in total

4 in total

1. Specific β-Defensins Stimulate Pruritus through Activation of Sensory Neurons.

Authors: Pang-Yen Tseng; Mark A Hoon
Journal: J Invest Dermatol Date: 2021-09-01 Impact factor: 7.590

2. Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons.

Authors: Sarah Ehling; Tomoki Fukuyama; Mei-Chuan Ko; Thierry Olivry; Wolfgang Bäumer
Journal: Acta Derm Venereol Date: 2019-05-01 Impact factor: 3.875

Review 3. From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine.

Authors: Laura Maintz; Thomas Bieber; Helen D Simpson; Anne-Laure Demessant-Flavigny
Journal: J Pers Med Date: 2022-05-28

4. GPR15L is an epithelial inflammation-derived pruritogen.

Authors: Pang-Yen Tseng; Mark A Hoon
Journal: Sci Adv Date: 2022-06-15 Impact factor: 14.957

4 in total