| Literature DB >> 29927845 |
Tessa van Middelaar1,2, Lonneke A van Vught3, Willem A van Gool1, Esther M F Simons2, Bert-Jan H van den Born4, Eric P Moll van Charante3, Edo Richard1,2.
Abstract
: Our objective was to study the preventive effect of lowering blood pressure (BP) by medication and/or lifestyle changes on incident all-cause dementia, Alzheimer's disease and vascular dementia. In this systematic review, we included randomized controlled trials with a BP-lowering intervention. Of the nine included trials, seven assessed the effect of antihypertensive medication and two of a lifestyle or combined intervention. In the intervention arm, 1041 out of 29 029 (3.6%) participants were diagnosed with dementia compared with 1090 out of 28 653 (3.8%) controls during a median follow-up of 3.9 years [range 2-10], resulting in a pooled risk ratio of 0.93 (95% confidence interval 0.84-1.02; I 16%). Three trials specified dementia subtypes, with no significant effect on Alzheimer's disease or vascular dementia. To conclude, lowering BP by medication and/or lifestyle changes did not lead to a significantly reduced risk of dementia. This appeared independent of dementia subtype.Entities:
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Year: 2018 PMID： 29927845 DOI： 10.1097/HJH.0000000000001829
Source DB: PubMed Journal: J Hypertens ISSN： 0263-6352 Impact factor: 4.844