Literature DB >> 2992652

Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets.

S Hamid, B J Whittle.   

Abstract

The anti-aggregating actions of prostaglandin D2 (PGD2) have been compared to prostacyclin (PGI2), its stable analogue carbacyclin and a hydantoin prostaglandin, BW245C, in guinea-pig PGI2, carbacyclin and BW245C were potent inhibitors of ADP-induced aggregation in guinea-pig platelets, with ID50 values comparable to those obtained in human platelet-rich-plasma. In contrast, PGD2 acted as a weak and partial inhibitor in guinea-pig platelet aggregation, producing a bell-shaped dose-response relationship. PGD2 induced a dose-related antagonism of the inhibitory actions of BW245C, prostacyclin and carbacyclin on guinea-pig platelets. However, PGD2 did not antagonize the inhibitory actions of either forskolin or dibutyryl cyclic AMP on this platelet preparation. The results suggest a non-specific interaction of PGD2 with these prostanoid binding sites on guinea-pig platelets.

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Year:  1985        PMID： 2992652      PMCID： PMC1916783          DOI： 10.1111/j.1476-5381.1985.tb08858.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  19 in total

1.  Identification of platelet receptors for prostaglandin I2 and D2.

Authors:  A I Schafer; B Cooper; D O'Hara; R I Handin
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

2.  Roles of cyclic nucleotides in platelet function.

Authors:  R J Haslam
Journal:  Ciba Found Symp       Date:  1975

3.  Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin.

Authors:  M Hamberg; B B Fredholm
Journal:  Biochim Biophys Acta       Date:  1976-04-22

4.  Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6-2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function.

Authors:  E W Salzman; L Levine
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808

5.  Conversions of prostaglandin endoperoxides by glutathione-S-transferases and serum albumins.

Authors:  E Christ-Hazelhof; D H Nugteren; D A Van Dorp
Journal:  Biochim Biophys Acta       Date:  1976-12-20

6.  Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets.

Authors:  J Svensson; M Hamberg; B Samuelsson
Journal:  Acta Physiol Scand       Date:  1975-06

7.  Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate and protein kinase.

Authors:  R Käser-Glanzmann; M Jakäbovä; J N George; E F Lüscher
Journal:  Biochim Biophys Acta       Date:  1977-05-02

8.  Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species.

Authors:  B J Whittle; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1978-09

9.  Ligand binding to thromboxane receptors on human platelets: correlation with biological activity.

Authors:  R A Armstrong; R L Jones; N H Wilson
Journal:  Br J Pharmacol       Date:  1983-08       Impact factor: 8.739

10.  Biosynthesis of prostaglandin D2. 1. Formation of prostaglandin D2 by human platelets.

Authors:  O Oelz; R Oelz; H R Knapp; B J Sweetman; J A Oates
Journal:  Prostaglandins       Date:  1977-02
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  5 in total

1.  Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets.

Authors:  S Hamid-Bloomfield; B J Whittle
Journal:  Br J Pharmacol       Date:  1986-08       Impact factor: 8.739

2.  Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Pathway Activation.

Authors:  Jiahua Zhang; Peishuang Yao; Wenli Han; Ying Luo; Yuke Li; Yang Yang; Hui Xia; Zhihao Chen; Qi Chen; Hong Wang; Lu Yang; Huan Li; Congli Hu; Haifeng Huang; Zhe Peng; Xiaodan Tan; Miaomiao Li; Junqing Yang
Journal:  Int J Mol Sci       Date:  2022-05-30       Impact factor: 6.208

3.  Characterization of the prostanoid receptor profile of enprostil and isomers in smooth muscle and platelets in vitro.

Authors:  R M Eglen; R L Whiting
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

4.  The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist.

Authors:  H Giles; P Leff; M L Bolofo; M G Kelly; A D Robertson
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

5.  Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C.

Authors:  S Hamid-Bloomfield; B J Whittle
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739
  5 in total

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