Literature DB >> 2992646

A monoclonal antibody D51 recognizes the transferrin-receptor structure.

H J Gross.   

Abstract

A monoclonal antibody D51 has been obtained during immunization against human fetal thymus. The antibody binds to a variety of leukemic cells. This is similar to the staining pattern of the mAb OKT9 and L 5.1, which recognize the transferrin receptor. However, there are some differences. The antibody immunoprecipitates a protein present on Molt-4 cells. Under reducing conditions this protein has a molecular weight of 90 K dalton. Under non-reducing conditions it has a molecular weight of 180 K dalton. This suggests a dimeric structure. The consecutive immunoprecipitation with D51 and OKT9, respectively, demonstrates that both antibodies recognize the structure of the transferrin receptor.

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Year:  1985        PMID： 2992646     DOI： 10.1007/bf00320120

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  21 in total

1.  A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors:  J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

2.  Identification of transferrin receptors on the surface of human cultured cells.

Authors:  T A Hamilton; H G Wada; H H Sussman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Transferrin binding by human lymphoblastoid cell lines and other transformed cells.

Authors:  G M Galbraith; R M Galbraith; W P Faulk
Journal:  Cell Immunol       Date:  1980-01       Impact factor: 4.868

5.  Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

Authors:  I S Trowbridge; F Lopez
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

6.  Isolation and characterization of normal rat kidney cell membrane proteins with affinity for transferrin.

Authors:  J A Fernandez-Pol; D J Klos
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162

7.  Identification of 125I-labeled rat reticulocyte membrane proteins with affinity for transferrin.

Authors:  A L Sullivan; L R Weintraub
Journal:  Blood       Date:  1978-08       Impact factor: 22.113

8.  A monoclonal antibody that detects expression of transferrin receptor in human erythroid precursor cells.

Authors:  D Lebman; M Trucco; L Bottero; B Lange; S Pessano; G Rovera
Journal:  Blood       Date:  1982-03       Impact factor: 22.113

9.  Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.

Authors:  E L Reinherz; P C Kung; G Goldstein; R H Levey; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

10.  Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

Authors:  R Sutherland; D Delia; C Schneider; R Newman; J Kemshead; M Greaves
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205
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